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Titolo:
Suramin-sensitive suppression of paired-pulse inhibition by adenine nucleotides in rat hippocampal slices
Autore:
Nikbakht, MR; Stone, TW;
Indirizzi:
Univ Glasgow, Inst Biomed & Life Sci, Glasgow G12 8QQ, Lanark, Scotland Univ Glasgow Glasgow Lanark Scotland G12 8QQ ow G12 8QQ, Lanark, Scotland
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 1-2, volume: 278, anno: 2000,
pagine: 45 - 48
SICI:
0304-3940(20000107)278:1-2<45:SSOPIB>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYNAPTIC TRANSMISSION; P-2-PURINOCEPTOR ANTAGONISTS; NORADRENALINE RELEASE; ECTO-NUCLEOTIDASES; MAMMALIAN NEURONS; VAS-DEFERENS; ATP; ADENOSINE; BRAIN; PURINOCEPTORS;
Keywords:
purines; adenosine; adenosine triphosphate; nucleotides; hippocampus; suramin; paired-pulse inhibition;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Stone, TW Univ Glasgow, Inst Biomed & Life Sci, W Med Bldg, Glasgow G12 8QQ, Lanark,Scotland Univ Glasgow W Med Bldg Glasgow Lanark Scotland G12 8QQ Scotland
Citazione:
M.R. Nikbakht e T.W. Stone, "Suramin-sensitive suppression of paired-pulse inhibition by adenine nucleotides in rat hippocampal slices", NEUROSCI L, 278(1-2), 2000, pp. 45-48

Abstract

In order to assess the possible presence of presynaptic P-2 receptors for nucleotides in the hippocampus, adenosine triphosphate and beta gamma-methyleneATP have been examined-on paired-pulse inhibition in rat hippocampal slices. Both compounds reproduced the effects of adenosine and reduced the amount of paired-pulse inhibition at an interpulse interval of 10 ms and increased the amount of facilitation at intervals of 20 and 50 ms. These effects were prevented by 8-phenyltheophylline and adenosine deaminase, indicating their mediation by adenosine. The effects were also reduced by suramin at50 mu M, suggesting the possible activation of P-2 receptors. It is suggested that a population of P-2 receptors may exist which promote the release of endogenous adenosine in the hippocampus. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 12:48:44