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Titolo:
Heme oxygenase-1, heme oxygenase-2 and biliverdin reductase in peripheral ganglia from rat, expression and plasticity
Autore:
Magnusson, S; Ekstrom, J; Elmer, E; Kanje, M; Ny, L; Alm, P;
Indirizzi:
Univ Lund, Dept Anim Physiol, Lund, Sweden Univ Lund Lund SwedenUniv Lund, Dept Anim Physiol, Lund, Sweden Univ Lund, Dept Clin Pharmacol, Lund, Sweden Univ Lund Lund SwedenUniv Lund, Dept Clin Pharmacol, Lund, Sweden Univ Lund, Dept Pathol, Lund, Sweden Univ Lund Lund SwedenUniv Lund, Dept Pathol, Lund, Sweden Univ Lund, Dept Neurol, Lund, Sweden Univ Lund Lund SwedenUniv Lund, Dept Neurol, Lund, Sweden Univ Gothenburg, Dept Pharmacol, Gothenburg, Sweden Univ Gothenburg Gothenburg Sweden g, Dept Pharmacol, Gothenburg, Sweden
Titolo Testata:
NEUROSCIENCE
fascicolo: 3, volume: 95, anno: 2000,
pagine: 821 - 829
SICI:
0306-4522(2000)95:3<821:HOHOAB>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; DORSAL-ROOT GANGLIA; MESSENGER-RNA; IMMUNOHISTOCHEMICAL LOCALIZATION; INSITU HYBRIDIZATION; CARBON-MONOXIDE; MOTOR-NEURONS; C-JUN; BRAIN; PROTEIN;
Keywords:
heme oxygenase; CO; peripheral ganglia; regeneration; in situ hybridization; immunocytochemistry; biliverdin reductase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Magnusson, S Univ Lund, Dept Anim Physiol, Lund, Sweden Univ Lund Lund Sweden und, Dept Anim Physiol, Lund, Sweden
Citazione:
S. Magnusson et al., "Heme oxygenase-1, heme oxygenase-2 and biliverdin reductase in peripheral ganglia from rat, expression and plasticity", NEUROSCIENC, 95(3), 2000, pp. 821-829

Abstract

The expression of inducible and constitutive heme oxygenase and biliverdinreductase was studied in normal and cultured peripheral ganglia from adultrats, using immunocytochemistry and in situ hybridization. Dramatic changes were induced by one to two days' culturing of dorsal root ganglia, nodoseganglia, otic ganglia, sphenopalatine ganglia and superior cervical ganglia. An up-regulation of inducible heme oxygenase was found in satellite cells of the cultured nodose ganglia, dorsal root ganglia, sphenopalatine ganglia and otic ganglia, whereas only a few satellite cells in the superior cervical ganglia responded with an increase in inducible heme oxygenase immunoreactivity. In the superior cervical ganglia inducible heme oxygenase also appeared in a subpopulation of macrophages. During culturing, expression ofinducible heme oxygenase immunoreactivity also increased in axons and in nerve cell bodies. In situ hybridization corroborated the immunocytochemicalfindings, revealing a strong up-regulation of inducible heme oxygenase messenger RNA in satellite cells, and less pronounced up-regulation in nerve cell bodies. Constitutive heme oxygenase immunoreactivity was found in most neurons in all of the ganglia studied. No significant changes in constitutive heme oxygenase immunoreactivity could be observed in cultured ganglia. Biliverdin reductase immunoreactivity was barely detectable in any of the normal ganglia; however, after culturing it appeared in axons, single nerve cell bodies and nerve cell nuclei. The results show that inducible heme oxygenase is up-regulated in peripheral ganglia after axonal injury, and suggest a role for carbon monoxide in cellular signaling and a requirement for the antioxidant (bilirubin) during the regeneration process. (C) 1999 IBRO. Published by Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 00:06:37