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Titolo:
Genotype influences in vivo dopamine transporter availability in human striatum
Autore:
Heinz, A; Goldman, D; Jones, DW; Palmour, R; Hommer, D; Gorey, JG; Lee, KS; Linnoila, M; Winberger, DR;
Indirizzi:
NIMH, Clin Brain Disorders Branch, DIRP, NIH, Bethesda, MD 20892 USA NIMHBethesda MD USA 20892 ders Branch, DIRP, NIH, Bethesda, MD 20892 USA NIAAA, Clin Studies Lab, DICBR, Bethesda, MD USA NIAAA Bethesda MD USANIAAA, Clin Studies Lab, DICBR, Bethesda, MD USA
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 2, volume: 22, anno: 2000,
pagine: 133 - 139
SICI:
0893-133X(200002)22:2<133:GIIVDT>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEALTHY-HUMAN SUBJECTS; BETA-CIT BINDING; ALCOHOL-WITHDRAWAL; NONHUMAN-PRIMATES; GENE POLYMORPHISM; ASSOCIATION; ADDICTION; BRAIN; RATS; NEUROBIOLOGY;
Keywords:
dopamine transporter; gene expression; SLC6A3; SPECT; beta-CIT; alcoholism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Winberger, DR NIMH, Clin Brain Disorders Branch, DIRP, NIH, 10 Ctr Dr,4S-235,MSC 1379, Bethesda, MD 20892 USA NIMH 10 Ctr Dr,4S-235,MSC 1379 BethesdaMD USA 20892 892 USA
Citazione:
A. Heinz et al., "Genotype influences in vivo dopamine transporter availability in human striatum", NEUROPSYCH, 22(2), 2000, pp. 133-139

Abstract

In vivo availability of striatal dopamine transporter (DAT) protein has been reported to be reduced among alcoholics, and allelic variation of the DAT gene (SLC6A3) has been associated with severity of alcohol withdrawal. Weexamined the VNTR polymorphism of the 3' untranslated region of SLC6A3 andDAT protein availability in 14 abstinent alcoholics and II control subjects. Single photon emission computed tomography (SPECT) and plasma levels of the radioligand [I-123]beta-CIT were used to quantify DAT protein availability. Individuals with the 9-repeat/10-repeat genotype had a mean 22% reduction of DAT protein availability in putamen compared with 10-repeat homozygous individuals (t = 2.14, df = 23, p <.05). Consistent with earlier studies, alcoholism, per se, was not significantly associated with either DAT availability or DAT genotype. These findings suggest that the VNTR polymorphismof the DAT gene effects translation of the DAT protein. This effect may explain a variety of clinical associations that have been reported with this polymorphism. Published by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 08:46:45