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Titolo:
The relationship between dorsolateral prefrontal neuronal N-acetylaspartate and evoked release of striatal dopamine in schizophrenia
Autore:
Bertolino, A; Breier, A; Callicott, JH; Adler, C; Mattay, VS; Shapiro, M; Frank, JA; Picker, D; Weiberger, DR;
Indirizzi:
NIMH, Intramural Res Program, Clin Brain Disorders Branch, NIH, Bethesda, MD 20892 USA NIMH Bethesda MD USA 20892 Disorders Branch, NIH, Bethesda, MD 20892 USA NIMH, Expt Therapeut Branch, Bethesda, MD 20892 USA NIMH Bethesda MD USA 20892 Expt Therapeut Branch, Bethesda, MD 20892 USA NIH, Lab Diagnost Radiol Res, OD, Bethesda, MD 20892 USA NIH Bethesda MD USA 20892 Diagnost Radiol Res, OD, Bethesda, MD 20892 USA
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 2, volume: 22, anno: 2000,
pagine: 125 - 132
SICI:
0893-133X(200002)22:2<125:TRBDPN>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE SPECTROSCOPY; POSITRON EMISSION TOMOGRAPHY; IN-VIVO; ACETYL ASPARTATE; H-1 MRS; CORTEX; LESIONS; RAT; DYSFUNCTION; EXPRESSION;
Keywords:
dorsolateral prefrontal cortex; N-acetylaspartate; striatum; dopamine; evoked release; schizophrenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Weiberger, DR NIMH, Intramural Res Program, Clin Brain Disorders Branch, NIH, 10 Ctr Dr,Room 4S235,MSC 1379, Bethesda, MD 20892 USA NIMH 10 Ctr Dr,Room 4S235,MSC 1379 Bethesda MD USA 20892 USA
Citazione:
A. Bertolino et al., "The relationship between dorsolateral prefrontal neuronal N-acetylaspartate and evoked release of striatal dopamine in schizophrenia", NEUROPSYCH, 22(2), 2000, pp. 125-132

Abstract

Schizophrenia has been linked to abnormal dopamine function, recently to excessive amphetamine-induced release of striatal dopamine, and also to pathology of prefrontal cortical neurons. It has been hypothesized that prefrontal pathology is a primary condition that leads to dopamine dysregulation. We evaluated in vivo the relationship between neuronal integrity in dorsolateral prefrontal cortex, assessed as N-acetylaspartate (NAA) relative concentrations measured with proton magnetic resonance spectroscopic imaging, and amphetamine-induced release of striatal dopamine, assessed with C-11-raclopride Positron Emission Tomography (PET) in patients wi;fh schizophrenia and in healthy subjects. In the patients, NAA measures in dorsolateral prefrontal cortex selectively predicted striatal displacement of C-11-racloprideafter amphetamine infusions (rho = -0.76, p <.02). In contrast, NAA measures in other cortical regions and in healthy subjects did not show any correlation. These results support the hypothesis that in schizophrenia neuronalpathology of dorsolateral prefrontal cortex is directly related to abnormal subcortical dopamine function. Published by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 11:57:48