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Titolo:
The relation between dopamine D-2 receptor density and personality: Preliminary evidence from the NEO personality inventory-revised
Autore:
Kestler, LP; Malhotra, AK; Finch, C; Adler, C; Breier, A;
Indirizzi:
NIMH, Expt Therapeut Branch, Bethesda, MD 20892 USA NIMH Bethesda MD USA 20892 Expt Therapeut Branch, Bethesda, MD 20892 USA Hillside Hosp, Unit Mol Psychiat, Glen Oaks, NY 11004 USA Hillside Hosp Glen Oaks NY USA 11004 ol Psychiat, Glen Oaks, NY 11004 USA American Univ, Dept Psychol, Washington, DC 20016 USA American Univ Washington DC USA 20016 t Psychol, Washington, DC 20016 USA Eli Lilly & Co, Indianapolis, IN 46285 USA Eli Lilly & Co Indianapolis INUSA 46285 & Co, Indianapolis, IN 46285 USA
Titolo Testata:
NEUROPSYCHIATRY NEUROPSYCHOLOGY AND BEHAVIORAL NEUROLOGY
fascicolo: 1, volume: 13, anno: 2000,
pagine: 48 - 52
SICI:
0894-878X(200001)13:1<48:TRBDDR>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION TOMOGRAPHY; NOVELTY SEEKING; MAJOR DEPRESSION; GENE; SCHIZOPHRENIA; POLYMORPHISM; ASSOCIATION; BINDING; TRAITS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Kestler, LP Emory Univ, 202 Psychol Bldg, Atlanta, GA 30322 USA Emory Univ202 Psychol Bldg Atlanta GA USA 30322 GA 30322 USA
Citazione:
L.P. Kestler et al., "The relation between dopamine D-2 receptor density and personality: Preliminary evidence from the NEO personality inventory-revised", NEUROPS NEU, 13(1), 2000, pp. 48-52

Abstract

Objective: To examine the relation between dopamine (DA) D-2 receptor-specific binding and personality, we assessed the relation between DA D-2 binding and the NEO Personality Inventory Revised (NEO PI-R). Background: Previous studies have demonstrated a relation between DA D-2 receptor-specific binding and a personality trait involving personal detachment as defined by the Karolinska Scales of Personality. A subsequent study using a different measure of personal detachment failed to replicate this finding, suggesting that metric properties of the personality scale may be important. To further examine this issue, we assessed the relation between DA D-2 binding and athird personality measure, the NEO PI-R. Methods: Eighteen adult subjects completed the NEO PI-R and participated in an C-11-raclopride positron emission tomography study to quantify striatal DA D-2 receptor binding. Results: We did not find a significant relation between binding and detachment-like traits on the NEO PI-R; however, we found a significant relation between DA D-2 receptor binding and the NEO PI-R personality facet of Depression (r= 0.75, p <0.0001). Conclusions: The results fail to replicate the findings of previous studies reporting an association between DA D-2 receptor density and personal detachment, suggesting that the relation is relatively specific to the trait defined by the Karolinska Scales of Personality. The relation between a nonclinical personality trait of depression and DA D-2 binding, if replicated, may help to elucidate the role of dopamine in depression.

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Documento generato il 31/03/20 alle ore 19:00:44