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Titolo:
A magnetization transfer histogram study of normal-appearing brain tissue in MS
Autore:
Tortorella, C; Viti, B; Bozzali, M; Sormani, MP; Rizzo, G; Gilardi, MF; Comi, G; Filippi, M;
Indirizzi:
Sci Inst Osped San Raffaele, Dept Neurosci, Neuroimaging Res Unit, I-20132Milan, Italy Sci Inst Osped San Raffaele Milan Italy I-20132 nit, I-20132Milan, Italy Sci Inst Osped San Raffaele, Dept Neurosci, Unit Clin Trials, I-20132 Milan, Italy Sci Inst Osped San Raffaele Milan Italy I-20132 ls, I-20132 Milan, Italy Sci Inst Osped San Raffaele, Dept Nucl Med, I-20132 Milan, Italy Sci Inst Osped San Raffaele Milan Italy I-20132 ed, I-20132 Milan, Italy Inst Canc Res, Unit Clin Epidemiol & Trials, Genoa, Italy Inst Canc Res Genoa Italy s, Unit Clin Epidemiol & Trials, Genoa, Italy
Titolo Testata:
NEUROLOGY
fascicolo: 1, volume: 54, anno: 2000,
pagine: 186 - 193
SICI:
0028-3878(20000111)54:1<186:AMTHSO>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRESSIVE MULTIPLE-SCLEROSIS; ATTENUATED INVERSION-RECOVERY; MRI LESION LOAD; SPIN-ECHO MRI; WHITE-MATTER; HYPOINTENSE LESIONS; MICROSCOPIC DISEASE; TRANSFER RATIO; DISABILITY; ABNORMALITIES;
Keywords:
MS; MRI; magnetization transfer imaging; normal-appearing brain tissue;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Filippi, M Sci Inst Osped San Raffaele, Dept Neurosci, Neuroimaging Res Unit, Via Olgettina 60, I-20132 Milan, Italy Sci Inst Osped San Raffaele Via Olgettina 60 Milan Italy I-20132
Citazione:
C. Tortorella et al., "A magnetization transfer histogram study of normal-appearing brain tissue in MS", NEUROLOGY, 54(1), 2000, pp. 186-193

Abstract

Objective: To evaluate 1) the ability of magnetization transfer ratio (MTR) histogram analysis to detect the extent of changes occurring outside MS lesions seen on conventional scans, 2) whether such changes vary in the different MS clinical phenotypes, 3) whether the changes are associated with the extent and severity of the macroscopic lesion load, and 4) the contribution to brain atrophy. Methods: Dual-echo, T1-weighted, and MT scans of the brain were obtained from 77 patients with varying MS courses and 20 age- andsex-matched control subjects. To create MT histograms of the normal-appearing cerebral tissue, MS lesions were segmented from dual-echo scans, superimposed automatically, and nulled out from the coregistered and scalp-stripped MTR maps. Average MTR, peak height, and peak position were considered. T2 and T1 lesion loads, average lesion MTR, and brain volume were also measured. Results: Average histogram MTR. (p < 0.0001) and peak position (p ( 0.0001) from patients with relapsing-remitting MS (RMMS) were lower than those from control subjects. Patients with primary progressive MS (PPMS) had lower average histogram MTR (p = 0.002) and histogram peak height (p = 0.01) than control subjects. Patients with secondary progressive MS (SPMS) had a lower peak height (p = 0.05) than those with RRMS. Average lesion MTR (p < 0.0001) correlated highly with the histogram MTR. Average histogram MTR (p < 0.0001) and T2 lesion load (p = 0.001) correlated highly with brain volume. Conclusions: The amount of microscopic changes account for an important fraction of the lesion load in MS. They may contribute to the development of brain atrophy and tend to be more evident in patients with secondary progressive MS.

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Documento generato il 03/07/20 alle ore 01:34:00