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Titolo:
Smoking habits in multiple system atrophy and progressive supranuclear palsy
Autore:
Vanacore, N; Bonifati, V; Fabbrini, G; Colosimo, C; Marconi, R; Nicholl, D; Bonuccelli, U; Stocchi, F; Lamberti, P; Volpe, G; De Michele, G; Iavarone, I; Bennett, P; Vieregge, P; Meco, G;
Indirizzi:
Univ La Sapienza, Dept Neurosci, I-00185 Rome, Italy Univ La Sapienza Rome Italy I-00185 , Dept Neurosci, I-00185 Rome, Italy Misericordia Hosp, Neurol Serv, Grosseto, Italy Misericordia Hosp Grosseto Italy dia Hosp, Neurol Serv, Grosseto, Italy Univ Birmingham, Dept Clin Neurol, Birmingham, W Midlands, England Univ Birmingham Birmingham W Midlands England ngham, W Midlands, England Univ Pisa, Inst Neurol, I-56100 Pisa, Italy Univ Pisa Pisa Italy I-56100Univ Pisa, Inst Neurol, I-56100 Pisa, Italy Univ Bari, Inst Neurol, I-70121 Bari, Italy Univ Bari Bari Italy I-70121Univ Bari, Inst Neurol, I-70121 Bari, Italy Univ Naples Federico II, Dept Neurol Sci, Naples, Italy Univ Naples Federico II Naples Italy II, Dept Neurol Sci, Naples, Italy Natl Inst Hlth, Lab Environm Hyg, Rome, Italy Natl Inst Hlth Rome ItalyNatl Inst Hlth, Lab Environm Hyg, Rome, Italy Univ Birmingham, Dept Psychiat, Birmingham, W Midlands, England Univ Birmingham Birmingham W Midlands England ngham, W Midlands, England Med Univ Lubeck, Dept Neurol, Lubeck, Germany Med Univ Lubeck Lubeck Germany niv Lubeck, Dept Neurol, Lubeck, Germany
Titolo Testata:
NEUROLOGY
fascicolo: 1, volume: 54, anno: 2000,
pagine: 114 - 119
SICI:
0028-3878(20000111)54:1<114:SHIMSA>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
PARKINSONS-DISEASE; CIGARETTE-SMOKING; ALZHEIMERS-DISEASE; GENETIC-EVIDENCE; NICOTINE; ASSOCIATION; MISCLASSIFICATION; POLYMORPHISM; DIAGNOSIS; INVOLVEMENT;
Keywords:
multiple system atrophy; progressive supranuclear palsy; smoking;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Vanacore, N Univ La Sapienza, Dept Neurosci, Viale Univ 30, I-00185 Rome, Italy Univ La Sapienza Viale Univ 30 Rome Italy I-00185 Rome, Italy
Citazione:
N. Vanacore et al., "Smoking habits in multiple system atrophy and progressive supranuclear palsy", NEUROLOGY, 54(1), 2000, pp. 114-119

Abstract

Objective: To evaluate smoking habits in patients with multiple system atrophy (MSA) and progressive supranuclear palsy (PSP) in a multicenter case-control study to determine whether these two forms of atypical parkinsonism share the inverse association with smoking previously found in PD. Background: No epidemiologic studies have been performed on smoking habits in MSA. A previous investigation in PSP revealed no differences in smoking habits between patients and hospital control subjects. Methods: Seventy-six MSA patients, 55 PSP patients, 140 PD patients, and 134 healthy control subjects were enrolled consecutively at seven neurologic clinics from January 1, 1994, to July 31, 1998. Detailed information on smoking habits was obtained using a structured questionnaire. Results: The comparison between frequencies of never-smokers versus ever-smokers (ex-smokers/current smokers; adjusted odds ratio [ORadj], 0.56; 95% CI, 0.29 to 1.06) and a dose-response analysis for never-smokers, moderate smokers (ORadj, 0.64; 95% CI, 0.31 to 1.32), and heavy smokers (ORadj, 0.47; 95% CI, 0.21 to 1.05) suggest that MSA patients smoke less than population control subjects. By contrast, the comparison of frequencies of never-smokers versus ever-smokers (ORadj, 0.91; 95% CI, 0.42 to 1.98) and a dose-response analysis for never-smokers, moderate smokers (ORadj, 0.68; 95% CI, 0.21 to 1.69), and heavy smokers (ORadj, 1.24; CI 95%, 0.51 to 3.06) revealed no differences in smoking habits between PSPpatients and population control subjects. Conclusions: The fact that the inverse association with smoking found previously in PD is shared by multiple system atrophy but not by progressive supranuclear palsy lends epidemiologic support to the notion that different smoking habits are associated withdifferent groups of neurodegenerative disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:40:33