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Titolo:
Nociceptin inhibits the neurogenic vasopressor response in the pithed rat via prejunctional ORL1 receptors
Autore:
Malinowska, B; Kozlowska, H; Koneczny, B; Schlicker, E;
Indirizzi:
Med Acad Bialystok, Dept Expt Physiol, PL-15230 Bialystok 8, Poland Med Acad Bialystok Bialystok Poland 8 siol, PL-15230 Bialystok 8, Poland Univ Bonn, Dept Pharmacol & Toxicol, D-53113 Bonn, Germany Univ Bonn Bonn Germany D-53113 harmacol & Toxicol, D-53113 Bonn, Germany
Titolo Testata:
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
fascicolo: 1, volume: 361, anno: 2000,
pagine: 80 - 84
SICI:
0028-1298(200001)361:1<80:NITNVR>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
ORPHAN OPIOID RECEPTOR; ENDOGENOUS LIGAND; ALPHA,BETA-METHYLENE ATP; NORADRENALINE RELEASE; MEDIATED INHIBITION; FQ; MOUSE;
Keywords:
nociceptin; orphanin FQ; opioid receptor-like receptor 1; prejunctional receptors; pithed rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Malinowska, B Med Acad Bialystok, Dept Expt Physiol, Mickiewicza 2A, PL-15230 Bialystok 8, Poland Med Acad Bialystok Mickiewicza 2A Bialystok Poland8 Poland
Citazione:
B. Malinowska et al., "Nociceptin inhibits the neurogenic vasopressor response in the pithed rat via prejunctional ORL1 receptors", N-S ARCH PH, 361(1), 2000, pp. 80-84

Abstract

Nociceptin (or orphanin FQ), the endogenous ligand for the opioid receptor-like 1 (ORL1) receptor, decreases blood pressure in the conscious and anesthetized rat. This study examined whether prejunctional inhibitory ORL1 receptors located on the postganglionic sympathetic neurons innervating the resistance vessels are detectable in pithed rats. In pithed and vagotomized rats electrical stimulation of the preganglionicsympathetic nerve fibers, injection of nicotine (2 mu mol/kg) or noradrenaline (1 nmol/kg) increased blood pressure by about 30 mmHg. The electrically induced vasopressor response was decreased dose-dependently by nociceptin(0.001-1 mu mol/kg; decrease by about 60% at 1 mu mol/kg). Nociceptin 0.1 mu mol/kg reduced the nicotine-induced vasopressor response by about 40% but at doses up to 1 mu mol/kg failed to affect the increase in blood pressure evoked by noradrenaline; The inhibitory action of nociceptin on the electrically and nice; tine-induced increase in blood pressure was attenuated bythe ORL1 receptor antagonists naloxone benzoylhydrazone (5 mu mol/kg) and/or [Phe(1)Psi(CH2-NN)Gly(2)]-nociceptin(1-13)NH2 (1 mu mol/kg) but was not affected by naloxone 10 mu mol/kg. In conclusion, the present data suggest that the postganglionic sympathetic nerve fibers innervating the resistance vessels of the rat are endowed with prejunctional ORL1 receptors, activation of which causes inhibition of noradrenaline release.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 08:12:45