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Titolo:
Bidirectional regulation of macrophage function by TGF-beta
Autore:
Ashcroft, GS;
Indirizzi:
Natl Inst Craniofacial & Dent Res, Oral Infect & Immun Branch, NIH, Bethesda, MD 20892 USA Natl Inst Craniofacial & Dent Res Bethesda MD USA 20892 sda, MD 20892 USA
Titolo Testata:
MICROBES AND INFECTION
fascicolo: 15, volume: 1, anno: 1999,
pagine: 1275 - 1282
SICI:
1286-4579(199912)1:15<1275:BROMFB>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSFORMING-GROWTH-FACTOR; INTERLEUKIN-1 RECEPTOR ANTAGONIST; FC-GAMMA-RIII; HUMAN-MONOCYTES; IN-VIVO; INFLAMMATORY RESPONSE; NEUTRALIZING ANTIBODY; ENDOTHELIAL-CELLS; HUMAN-PLATELETS; EXPRESSION;
Keywords:
TGF-beta; macrophage function; deactivation; reactivation; bidirectional regulation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
87
Recensione:
Indirizzi per estratti:
Indirizzo: Ashcroft, GS Natl Inst Craniofacial & Dent Res, Oral Infect & Immun Branch, NIH, Bethesda, MD 20892 USA Natl Inst Craniofacial & Dent Res Bethesda MD USA 20892 USA
Citazione:
G.S. Ashcroft, "Bidirectional regulation of macrophage function by TGF-beta", MICROBES IN, 1(15), 1999, pp. 1275-1282

Abstract

The dual role of transforming growth factor-beta (TGF-beta) in modulating macrophage function is an important concept gaining increasing recognition. In addition to its role as a 'macrophage-deactivating' agent, TGF-beta functions as a monocyte activator, inducing cytokine production and mediating host defence. These functions are context-dependent, modulated by the differentiation state of the cell, the local cytokine environment, and the locallevels of TGF-beta in itself. In general, during the initial stages of inflammation, TGF-beta locally acts as a proinflammatory agent by recruiting and activating resting monocytes. As these cells differentiate specific immunosuppressive actions of TGF-beta predominate, leading to resolution of theinflammatory response. Increasing our understanding of the bidirectional regulation of macrophage function will facilitate prediction of the ultimateoutcome of modulating TGF-beta levels in vivo. (C) 1999 Editions scientifiques et medicales Elsevier SAS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 20:40:37