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Titolo:
Evidence for increased nitric oxide production in the auditory brain stem of the aged dwarf hamster (Phodopus sungorus): an NADPH-diaphorase histochemical study
Autore:
Reuss, S; Schaeffer, DF; Laages, MH; Riemann, R;
Indirizzi:
Univ Mainz, Sch Med, Dept Anat, D-55099 Mainz, Germany Univ Mainz Mainz Germany D-55099 Med, Dept Anat, D-55099 Mainz, Germany Univ Wurzburg, Dept Otorhinolaryngol, D-97070 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97070 ryngol, D-97070 Wurzburg, Germany
Titolo Testata:
MECHANISMS OF AGEING AND DEVELOPMENT
fascicolo: 2, volume: 112, anno: 2000,
pagine: 125 - 134
SICI:
0047-6374(20000103)112:2<125:EFINOP>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUPRACHIASMATIC NUCLEUS; NERVOUS-SYSTEM; HEARING-LOSS; NEURONS; PATHWAY;
Keywords:
auditory brain stem; cochlea; hamster; intermediolateral nucleus; NADPH-diaphorase; neuronal nitric oxide synthase; Phodopus sungorus; spinal cord; superior olivary complex;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Reuss, S Univ Mainz, Sch Med, Dept Anat, Saarstr 19-21, D-55099 Mainz, Germany Univ Mainz Saarstr 19-21 Mainz Germany D-55099 99 Mainz, Germany
Citazione:
S. Reuss et al., "Evidence for increased nitric oxide production in the auditory brain stem of the aged dwarf hamster (Phodopus sungorus): an NADPH-diaphorase histochemical study", MECH AGE D, 112(2), 2000, pp. 125-134

Abstract

Age-related changes of the auditory system such as presbyacusis are believed to be due, at least in part, to alterations of central structures. The superior olivary complex (SOC), a group of interrelated brain stem nuclei, projects to a variety of neuronal structures including the cochlea and the inferior colliculus (IC). The soluble gas nitric oxide (NO), believed to function as a neuroactive substance within the SOC and cochlea, is thought to be involved in ageing processes. Since it is unknown whether NO-production is altered in the ageing auditory system, the present study was conducted to investigate whether the number of NO-producing cells in the SOC is changed with increasing age. The histochemical detection of NADPH-diaphorase activity (NADPH-d), a marker for neurons containing NOS, was utilized to investigate the numbers of NO-producing cells in the SOC of adult and senile Djungarian dwarf hamsters (Phodopus sungorus). Our results demonstrate that thenumber of stained neurons was almost doubled in the SOC of senile hamsters. The most distinct changes were observed in the medial nucleus of the trapezoid body. In contrast, NO-producing preganglionic sympathetic neurons of the spinal intermediolateral nucleus, which was studied for comparison, didnot exhibit significant differences between adult and senile animals. It is concluded that the increase of NO-production in the ageing auditory brainstem, as revealed by our data, may be related to hearing impairments with increasing age. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 21:59:04