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Titolo:
Effects of red ginseng saponins and nootropic drugs on impaired acquisition of ethanol-treated rats in passive avoidance performance
Autore:
Lee, SC; Moon, YS; You, KH;
Indirizzi:
Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea Chungnam Natl Univ Taejon South Korea 305764 Taejon 305764, South Korea Chungnam Natl Univ, Coll Nat Sci, Taejon 305764, South Korea Chungnam NatlUniv Taejon South Korea 305764 Taejon 305764, South Korea
Titolo Testata:
JOURNAL OF ETHNOPHARMACOLOGY
fascicolo: 1, volume: 69, anno: 2000,
pagine: 1 - 8
SICI:
0378-8741(20000101)69:1<1:EORGSA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
MICE; NEUROTRANSMITTERS; BEHAVIOR; DOPAMINE; ALCOHOL;
Keywords:
acquisition; ethanol; alpha-methyl-rho-tyrosine; nootropic drug; red ginseng total saponin; repeated administration;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Lee, SC Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea Chungnam Natl Univ Taejon South Korea 305764 305764, South Korea
Citazione:
S.C. Lee et al., "Effects of red ginseng saponins and nootropic drugs on impaired acquisition of ethanol-treated rats in passive avoidance performance", J ETHNOPHAR, 69(1), 2000, pp. 1-8

Abstract

Effects of single and repeated administration of red ginseng total saponins (ROTS) and nootropic drugs were examined on impairment of acquisition induced by single oral administration of 3 g/kg ethanol (EtOH) in a step through test. The inhibitory effect of EtOH on acquisition was significantly reduced following single or repeated RGTS administration. The nootropic drugs,piracetam and N-methyl-D-glucamine, given orally significantly reduced impairment of acquisition induced by EtOH. On the other hand, the inhibitory effect of repeated RGTS on the EtOH-induced amnesia was blocked by the pretreatment of alpha-methyl-rho-tyrosine (alpha-MT), an inhibitor of catecholamine synthesis, in a dose-dependent manner but not rho-chlorophenylalanine (PCPA), an inhibitor of serotonin synthesis, whereas the inhibitory effect of repeated N-methyl-D-glucamine on the EtOH-induced amnesia was blocked neither by alpha-MT nor PCPA. These results suggest that repeated RGTS and N-methyl-D-glucamine ameliorate the impairing effect of EtOH on acquisition, and the effect of RGTS on EtOH-induced amnesia is dependent on the catecholaminergic but not serotonergic neuronal activity, while RGTS and N-methyl-D-glucamine seem to have a different mechanism on EtOH-induced amnesia. (C) 2000 Published by Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/21 alle ore 14:20:56