Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
CagA antibodies in Japanese children with nodular gastritis or peptic ulcer disease
Autore:
Kato, S; Sugiyama, T; Kudo, M; Ohnuma, K; Ozawa, K; Iinuma, K; Asaka, M; Blaser, MJ;
Indirizzi:
Tohoku Univ, Sch Med, Dept Pediat, Aoba Ku, Sendai, Miyagi 9808574, Japan Tohoku Univ Sendai Miyagi Japan 9808574 Ku, Sendai, Miyagi 9808574, Japan Hokkaido Univ, Sch Med, Dept Internal Med 3, Sapporo, Hokkaido 060, Japan Hokkaido Univ Sapporo Hokkaido Japan 060 3, Sapporo, Hokkaido 060, Japan Vanderbilt Univ, Sch Med, Dept Med, Nashville, TN 37212 USA Vanderbilt Univ Nashville TN USA 37212 Dept Med, Nashville, TN 37212 USA Vanderbilt Univ, Sch Med, Dept Immunol & Microbiol, Nashville, TN 37212 USA Vanderbilt Univ Nashville TN USA 37212 Microbiol, Nashville, TN 37212 USA
Titolo Testata:
JOURNAL OF CLINICAL MICROBIOLOGY
fascicolo: 1, volume: 38, anno: 2000,
pagine: 68 - 70
SICI:
0095-1137(200001)38:1<68:CAIJCW>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
HELICOBACTER-PYLORI STRAINS; EPITHELIAL-CELLS; INFECTION; EXPRESSION; DIAGNOSIS; CYTOTOXIN; PROTEIN; GENE; ERADICATION; VIRULENCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Kato, S Tohoku Univ, Sch Med, Dept Pediat, Aoba Ku, 1-1 Seiryo Machi, Sendai, Miyagi 9808574, Japan Tohoku Univ 1-1 Seiryo Machi Sendai Miyagi Japan 9808574 74, Japan
Citazione:
S. Kato et al., "CagA antibodies in Japanese children with nodular gastritis or peptic ulcer disease", J CLIN MICR, 38(1), 2000, pp. 68-70

Abstract

cagA(+) Helicobacter pylori strains have been linked to more severe gastric inflammation, peptic ulcer disease, and gastric cancer in adults, but there have been fen studies of cagA in children, me examined the relationship between H. pylori cagA status and clinical status in Japanese children. Forty H. pylori-positive children were studied: 15 with nodular gastritis, 5 with gastric ulcers, and 20 with duodenal ulcers. H. pylori status was confirmed by biopsy-based tests and serum anti-H, pylori immunoglobulin G (IgG) antibody. As controls, 77 asymptomatic children with sera positive for anti->. pylori IgG were enrolled. Levels of IgG antibodies to CagA in serum were measured by an antigen-specific enzyme-linked immunosorbent assay. In 16 patients with successful H. pylori eradication, posttreatment levels of CagA. and H. pylori IgG antibodies also were studied. The CagA antibody seropositivities of asymptomatic controls (81.8%) and patients with nodular gastritis, gastric ulcers, and duodenal ulcers (80.0 to 95.0%) were not significantly different. Compared with pretreatment levels of CagA antibodies, posttreatment levers decreased progressively and significantly. We conclude that, as in Japanese adults, a high prevalence of cagA(+) H. pylori strains was found in Japanese children, and that there was no association with nodular gastritis or peptic ulcer disease. In the assessment of eradicative therapies, monitoring of serum anti-CagA antibodies does not appear to offer anydirect benefit over monitoring of anti-H. pylori antibodies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 19:30:02