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Titolo:
Steroid hormone receptors: Evolution, ligands, and molecular basis of biologic function
Autore:
Whitfield, GK; Jurutka, PW; Haussler, CA; Haussler, MR;
Indirizzi:
Univ Arizona, Coll Med, Dept Biochem, Tucson, AZ 85724 USA Univ Arizona Tucson AZ USA 85724 Med, Dept Biochem, Tucson, AZ 85724 USA
Titolo Testata:
JOURNAL OF CELLULAR BIOCHEMISTRY
, , anno: 1999, supplemento:, 32-33
pagine: 110 - 122
SICI:
0730-2312(1999):<110:SHRELA>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
RETINOID-X-RECEPTOR; VITAMIN-D-RECEPTOR; NUCLEAR RECEPTORS; BINDING DOMAIN; TRANSCRIPTIONAL ACTIVATION; STRUCTURAL DETERMINANTS; GENOMIC ORGANIZATION; CRYSTAL-STRUCTURE; ORPHAN RECEPTOR; DNA-BINDING;
Keywords:
nuclear receptor phylogeny; steroid biosynthesis; hormonal control of gene transcription; zinc-finger proteins; hormone-responsive elements;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Haussler, MR Univ Arizona, Coll Med, Dept Biochem, Tucson, AZ 85724 USA Univ Arizona Tucson AZ USA 85724 ochem, Tucson, AZ 85724 USA
Citazione:
G.K. Whitfield et al., "Steroid hormone receptors: Evolution, ligands, and molecular basis of biologic function", J CELL BIOC, 1999, pp. 110-122

Abstract

The characterization of the superfamily of nuclear receptors, in particular the steroid/retinoid/thyroid hormone receptors, has resulted in a more complete understanding of how a repertoire of hormonally and nutritionally derived lipophilic ligands controls cell functions to effect development and homeostasis. As transducers of hormonal signaling in the nucleus, this superfamily of DNA-binding proteins appears to represent a crucial link in the emergence of multicellular organisms. Because nuclear receptors bind and are conformationally activated by a chemically diverse array of ligands, yet are closely related in general structure, they present an intriguing example of paralogous evolution. It is hypothesized that an ancient prototype receptor evolved into an intricate set of dimerizing isoforms, capable of recognizing an ensemble of hormone-responsive element motifs in DNA, and exerting ligand-directed combinatorial control of gene expression. The effector domains of nuclear receptors mediate transcriptional activation by recruiting coregulatory multisubunit complexes that remodel chromatin, target the initiation site, and stabilize the RNA polymerase II machinery for repealed rounds of transcription of the regulated gene. Because some nuclear receptors also function in gene repression, while others are constitutive activators, this superfamily of proteins provides a number of avenues far investigating hormonal regulation of gene expression. This review surveys briefly thelatest findings in the nuclear receptor field and identifies particular areas where future studies should be fruitful. (C) 1999 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 13:45:40