Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Pulmonary vasoregulation by endothelin in conscious dogs after left lung transplantation
Autore:
Doi, S; Smedira, N; Murray, PA;
Indirizzi:
Cleveland Clin Fdn, Ctr Anesthesiol Res, Cleveland, OH 44195 USA ClevelandClin Fdn Cleveland OH USA 44195 ol Res, Cleveland, OH 44195 USA Cleveland Clin Fdn, Dept Thorac & Cardiovasc Surg, Cleveland, OH 44195 USACleveland Clin Fdn Cleveland OH USA 44195 c Surg, Cleveland, OH 44195 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 1, volume: 88, anno: 2000,
pagine: 210 - 218
SICI:
8750-7587(200001)88:1<210:PVBEIC>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRONCHOALVEOLAR LAVAGE FLUID; SMOOTH-MUSCLE CONTRACTION; RECEPTOR ANTAGONIST; BLOOD-VESSELS; RAT LUNGS; IN-VIVO; HYPERTENSION; VASOCONSTRICTION; AUTOTRANSPLANTATION; ANESTHESIA;
Keywords:
pulmonary vascular pressure-flow relationship; endothelin-receptor antagonists; hypoxic pulmonary vasoconstriction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Murray, PA Cleveland Clin Fdn, Ctr Anesthesiol Res, FF40,9500 Euclid Ave, Cleveland, OH 44195 USA Cleveland Clin Fdn FF40,9500 Euclid Ave Cleveland OH USA 44195
Citazione:
S. Doi et al., "Pulmonary vasoregulation by endothelin in conscious dogs after left lung transplantation", J APP PHYSL, 88(1), 2000, pp. 210-218

Abstract

We tested the hypothesis that regulation of the pulmonary circulation by endogenous endothelin (ET) during normoxia and hypoxia was altered in conscious dogs 1 mo after left lung autotransplantation (LLA). Sham-operated control and post-LLA dogs were chronically instrumented to measure the left pulmonary vascular pressure-flow (LP-Q) relationship. LP-Q plots were generated on separate days during normoxia and hypoxia (arterial Po-2 similar to 50Torr) in the intact condition, after selective ETA-receptor inhibition (BQ-485), and after combined ETA+B-receptor inhibition (bosentan). Although LLA resulted in a chronic increase in pulmonary vascular resistance, the ET-receptor antagonists had no effect on the LP-Q relationship during normoxia in either group. The magnitude of hypoxic pulmonary vasoconstriction (HPV) was flow dependent in both groups, and the HPV response was potentiated post-LLA compared with control. ETA-receptor inhibition attenuated the HPV response to the same extent in both groups. ETA+B-receptor inhibition attenuated the HPV response to a greater extent than did ETA-receptor inhibition alone, and this effect was greater post-LLA compared with control. Plasma ET-1 concentration only increased during hypoxia in the LLA group. These results indicate that ET does not regulate the baseline LP-Q relationship in either group. Both ETA- and ETB-receptor activation mediate a component of HPVin conscious dogs, and the vasoconstrictor influence of ETB-receptor activation is enhanced post-LLA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 11:10:21