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Titolo:
ERK/MAPK pathway is required for changes of cyclin D1 and B1 during phorbol 12-myristate 13-acetate-induced differentiation of K562 cells
Autore:
Lee, CH; Yun, HJ; Kang, HS; Kim, HD;
Indirizzi:
Pusan Natl Univ, Coll Nat Sci, Dept Mol Biol, Pusan 609735, South Korea Pusan Natl Univ Pusan South Korea 609735 Biol, Pusan 609735, South Korea
Titolo Testata:
IUBMB LIFE
fascicolo: 6, volume: 48, anno: 1999,
pagine: 585 - 591
SICI:
1521-6543(199912)48:6<585:EPIRFC>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-C; CDK INHIBITOR; ACTIVATION; ARREST; P21; EXPRESSION; GROWTH; PROLIFERATION; INDUCTION; U937;
Keywords:
cyclin B1; cyclin D1; ERK; K562 cell; PD098059; PMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Kim, HD Pusan Natl Univ, Coll Nat Sci, Dept Mol Biol, Pusan 609735, South Korea Pusan Natl Univ Pusan South Korea 609735 san 609735, South Korea
Citazione:
C.H. Lee et al., "ERK/MAPK pathway is required for changes of cyclin D1 and B1 during phorbol 12-myristate 13-acetate-induced differentiation of K562 cells", IUBMB LIFE, 48(6), 1999, pp. 585-591

Abstract

Phorbol 12-myristate 13-acetate (BMA)-induced differentiation of human erythroleukemic K562 cells is characterized by growth arrest, morphological change, and expression of megakaryocyte-specific proteins. We examined the possible involvement of cell cycle regulators with PMA-induced growth arrest and megakaryocytic differentiation of K562 cells. The concentrations of cyclin D1 and p21(Waf1/Cip1) were dramatically increased, whereas those of cyclin B1 and cdc2 were decreased, by PMA treatment. The concentrations of most cyclin-dependent kinases (Cdk2, Cdk4, and Cdk6), however, were unchanged by PMA treatment. PD98059, a specific inhibitior of MEK1, partially prevented the increase in cyclin D1 caused by PMA and fully reversed the down-regulation of cyclin B1 protein seen in response to PMA treatment. Thus, it is demonstrated here that the PMA-mediated changes of cyclin D1 and B1 are theresult of a persistent increase in extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK) activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 07:00:01