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Titolo:
Angiogenesis for the treatment of vascular diseases
Autore:
Chawla, PS; Keelan, MH; Kipshidze, N;
Indirizzi:
Med Coll Wisconsin, Dept Cardiovasc Med, Milwaukee, WI 53226 USA Med Coll Wisconsin Milwaukee WI USA 53226 sc Med, Milwaukee, WI 53226 USA
Titolo Testata:
INTERNATIONAL ANGIOLOGY
fascicolo: 3, volume: 18, anno: 1999,
pagine: 185 - 192
SICI:
0392-9590(199909)18:3<185:AFTTOV>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIBROBLAST GROWTH-FACTOR; PERIPHERAL ARTERY DISEASE; FIBRIN GLUE; RABBIT MODEL; THERAPEUTIC ANGIOGENESIS; LIMB ISCHEMIA; MYOCARDIUM; HEART; REVASCULARIZATION; INVIVO;
Keywords:
peripheral vascular diseases; leg blood supply; neorevascularization, physiologic drug effects; endothelial growth factors;
Tipo documento:
Editorial Material
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Kipshidze, N Med Coll Wisconsin, Dept Cardiovasc Med, 9200 W Wisconsin Ave, Milwaukee, WI 53226 USA Med Coll Wisconsin 9200 W Wisconsin Ave MilwaukeeWI USA 53226
Citazione:
P.S. Chawla et al., "Angiogenesis for the treatment of vascular diseases", INT ANGIOL, 18(3), 1999, pp. 185-192

Abstract

Critical ischemia of the limbs or myocardium is frequently accompanied by diffuse distal vascular disease making it unapproachable by conventional revascularization techniques. Pharmacological treatment is available for coronary artery disease but there has been no effective medical therapy for advanced ischemia of the limbs. In the search for alternative treatments for patients with diffuse distal disease, recent developments in vascular biology have directed attention towards use of Vascular growth factors. Therapeutic angiogenesis has shown promising results in early clinical studies as shown by improved clinical status and in some cases angiographic studies. We employed an angiogenic strategy that utilizes enhanced vascular endothelialgrowth factor (VEGF) in a fibrin network, in two patients with critical limb ischemia. Objectively, we were able to demonstrate angiographically the growth of new blood vessels after administration of VEGF and fibrin composite. Fibrin glue provides for the slow release of and prolongs the availability of VEGF, thereby sustaining angiogenesis resulting in improved oxygenation of ischemic tissue. Further investigations are warranted to validate ifangiogenesis may increase blood flow in patients with advanced vascular disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 08:16:02