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Titolo:
Effects of sildenafil (Viagra (TM)) administration on seminal parameters and post-ejaculatory refractory time in normal males
Autore:
Aversa, A; Mazzilli, F; Rossi, T; Delfino, M; Isidori, AM; Fabbri, A;
Indirizzi:
Univ Rome La Sapienza, Dipartimento Fisiopatol Med, Cattedra Androl, Rome,Italy Univ Rome La Sapienza Rome Italy patol Med, Cattedra Androl, Rome,Italy St Bartholomews Hosp, Dept Endocrinol, London, England St Bartholomews Hosp London England p, Dept Endocrinol, London, England
Titolo Testata:
HUMAN REPRODUCTION
fascicolo: 1, volume: 15, anno: 2000,
pagine: 131 - 134
SICI:
0268-1161(200001)15:1<131:EOS((A>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN MONOAMINERGIC CONTROL; MALE REPRODUCTIVE-BEHAVIOR; ERECTILE DYSFUNCTION; PHOSPHODIESTERASE; SEROTONIN; RECEPTOR; MOTILITY; DOPAMINE; PERIOD;
Keywords:
ejaculation; erectile function; phosphodiesterase inhibitor; reproductive behaviour; semen;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Aversa, A Policlin Umberto I, Dipartimento Fisiopatol Med, Cattedra Androl, Viale Policlin, I-00161 Rome, Italy Policlin Umberto I Viale Policlin Rome Italy I-00161 ome, Italy
Citazione:
A. Aversa et al., "Effects of sildenafil (Viagra (TM)) administration on seminal parameters and post-ejaculatory refractory time in normal males", HUM REPR, 15(1), 2000, pp. 131-134

Abstract

Sildenafil is a specific inhibitor of phosphodiesterase (PDE) type 5 and represents a powerful therapy for male erectile dysfunction (ED) of different aetiology. Recently, sildenafil has been shown to restore erections in temporary ED related to the need of semen collection for assisted reproductive techniques. In this study, we investigated whether sildenafil administration modifies seminal parameters and/or erectile function in normal healthy volunteers. In a double-blind, randomized, placebo-controlled, cross-over two period investigation we enrolled 20 healthy male volunteers (mean +/- SEage 32 +/- 0.5 years). Subjects were not using any medication for the 3 month period prior to the study and were engaged in a stable relationship with proven fertility, The effects of sildenafil (100 mg) on seminal parameters and erectile function after audiovisual sexual stimulation were evaluatedby semen analysis and by colour-Duplex ultrasound (the Resistive Index) respectively, In all subjects, sildenafil caused no changes in seminal and erection parameters when compared to placebo. Interestingly, sildenafil administration led to a marked reduction of the postejaculatory refractory time (10.8 +/- 0.9 min versus 2.6 +/- 0.7 min for placebo and sildenafil respectively; P < 0.0001), These results indicate that in normal subjects acute sildenafil treatment does not modify semen characteristics and has a positiveinfluence over the resumption of erections following ejaculation in the presence of a continuous erotic stimulus.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 08:57:36