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Titolo:
Cortically driven Fos induction in the striatum is amplified by local dopamine D2-class receptor blockade
Autore:
Berretta, S; Sachs, Z; Graybiel, AM;
Indirizzi:
MIT, Dept Brain & Cognit Sci, Cambridge, MA 02139 USA MIT Cambridge MA USA 02139 pt Brain & Cognit Sci, Cambridge, MA 02139 USA
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 12, volume: 11, anno: 1999,
pagine: 4309 - 4319
SICI:
0953-816X(199912)11:12<4309:CDFIIT>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
EARLY GENE-EXPRESSION; INVIVO PRESYNAPTIC CONTROL; IMMEDIATE-EARLY GENES; CAT CAUDATE-NUCLEUS; BASAL GANGLIA; C-FOS; PARKINSONS-DISEASE; RAT STRIATUM; SYNAPTIC PLASTICITY; NMDA RECEPTORS;
Keywords:
frontal cortex; haloperidol; immediate-early gene; neuroleptic; picrotoxin; sulpiride;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
82
Recensione:
Indirizzi per estratti:
Indirizzo: Graybiel, AM MIT, Dept Brain & Cognit Sci, E25-618, Cambridge, MA 02139 USA MIT E25-618 Cambridge MA USA 02139 8, Cambridge, MA 02139 USA
Citazione:
S. Berretta et al., "Cortically driven Fos induction in the striatum is amplified by local dopamine D2-class receptor blockade", EUR J NEURO, 11(12), 1999, pp. 4309-4319

Abstract

Dopamine D2-class receptors have been shown to control the excitability ofstriatal neurons in response to cortical activation. It has been unclear, however, whether such receptors could regulate the number of striatal neurons activated by cortical stimulation, and thus affect the population response of the striatum to its cortical inputs. We used Fos induction as a readout to measure the ensemble response of striatal neurons to localized stimulation of the frontal cortex and tested for the effects of D2-class dopaminereceptor blockade on this response. In freely moving rats, we stimulated the frontal cortex by local epidural application of a dose of a GABA(A) receptor antagonist (picrotoxin) just threshold for inducing Fos in the striatum. We combined this treatment with D2-class dopamine receptor antagonist treatments at dose levels also just threshold for inducing Fos, using either (i) systemic haloperidol or (ii) intrastriatal (-)sulpiride. Both systemic and intrastriatal blockade of D2-class receptors sharply increased the numbers of striatal neurons exhibiting cortically evoked Fos induction. These findings suggest that local activation of intrastriatal D2-class dopamine receptors can regulate the number of striatal neurons responsive to cortical inputs, thus dynamically shaping the flow of information through the striatum.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 13:09:35