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Titolo:
Intracellular biology of Alzheimer's disease amyloid beta peptide
Autore:
Hartmann, T;
Indirizzi:
Univ Heidelberg, Ctr Mol Biol, ZMBH, D-69120 Heidelberg, Germany Univ Heidelberg Heidelberg Germany D-69120 , D-69120 Heidelberg, Germany
Titolo Testata:
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
fascicolo: 6, volume: 249, anno: 1999,
pagine: 291 - 298
SICI:
0940-1334(199912)249:6<291:IBOADA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
INSOLUBLE MEMBRANE COMPARTMENT; HUMAN NEUROBLASTOMA-CELLS; PAIRED HELICAL FILAMENTS; PRECURSOR PROTEIN; ENDOPLASMIC-RETICULUM; SECRETASE CLEAVAGE; IN-VIVO; HIPPOCAMPAL-NEURONS; NONNEURONAL CELLS; DISTINCT SITES;
Keywords:
cell biology; endoplasmic reticulum; Golgi trans Golgi network; amyloid; Alzheimer's disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
81
Recensione:
Indirizzi per estratti:
Indirizzo: Hartmann, T Univ Heidelberg, Ctr Mol Biol, ZMBH, Neuenheimer Feld 282, D-69120 Heidelberg, Germany Univ Heidelberg Neuenheimer Feld 282 Heidelberg Germany D-69120
Citazione:
T. Hartmann, "Intracellular biology of Alzheimer's disease amyloid beta peptide", EUR ARCH PS, 249(6), 1999, pp. 291-298

Abstract

Strong evidence links excess production of a small peptide and the pathogenesis of Alzheimer's disease (AD). Originally this peptide, beta-amyloid 42(A beta 42), was assumed to be released by a pathogenic event; it is now well established that A beta 42 is released from cells during normal cellular metabolism of the Alzheimer amyloid precursor protein. Recently, in a series of surprising reports it was discovered that A beta 42 is produced intracellularly, and what might have been regarded first as a strange abnormality of a few selected cell lines has now been recognized as an important cellular pathway for A beta production. Moreover, the differences between secretory and intracellular A beta production might hold the clues for brain specificity and cellular mechanisms of AD pathogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 19:48:07