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Titolo:
Structural neuroimaging in schizophrenia - An integrative view of neuromorphology
Autore:
Henn, FA; Braus, DF;
Indirizzi:
Cent Inst Mental Hlth ZI, D-68072 Mannheim, Germany Cent Inst Mental Hlth ZI Mannheim Germany D-68072 8072 Mannheim, Germany
Titolo Testata:
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
, volume: 249, anno: 1999, supplemento:, 4
pagine: 48 - 56
SICI:
0940-1334(1999)249:<48:SNIS-A>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE SPECTROSCOPY; CEREBRAL BLOOD-FLOW; DORSOLATERAL PREFRONTAL CORTEX; POSITRON EMISSION TOMOGRAPHY; PLANUM TEMPORALE ASYMMETRY; VERBAL FLUENCY TASK; CARD SORTING TEST; VENTRICULAR ENLARGEMENT; BRAIN ABNORMALITIES; SELECTIVE ATTENTION;
Keywords:
schizophrenia; MRI; structure; brain volume;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
147
Recensione:
Indirizzi per estratti:
Indirizzo: Henn, FA Cent Inst Mental Hlth ZI, POB 122 120, D-68072 Mannheim, Germany Cent Inst Mental Hlth ZI POB 122 120 Mannheim Germany D-68072 ny
Citazione:
F.A. Henn e D.F. Braus, "Structural neuroimaging in schizophrenia - An integrative view of neuromorphology", EUR ARCH PS, 249, 1999, pp. 48-56

Abstract

The use of structural magnetic resonance imaging (MRI) in studies of schizophrenia has resulted in a more detailed picture of anatomic areas which may be altered in this syndrome. Thus far, there have been over 130 studies of schizophrenia using MRI and, taken together, they present a clear pictureof a group of disorders with altered brain structure. Their major finding is a confirmation of the older pneumoencephalography and computer-tomography studies showing an enlargement of lateral ventricles and a volume reduction seen in the temporal lobe. When structural studies are carried out in other cortical and subcortical regions, however, the volume reduction is not so uniform, but rather restricted to certain areas in a given patient. In addition medication effects can be seen especially in the caudate nucleus which tend to increase in volume after long-term neuroleptic drug usage and again normalize under the atypical drug clozapine. These data are consistentwith a neurodevelopmental model of schizophrenia and with some kind of progressive neurodegenerative process. This review suggests that an integrative model with initial developmental errors may underlie the majority of cases of schizophrenia, but that cases of chronic schizophrenia appear to involve progressive neurodegeneration. In assessing the scatter in available data, it appears that there is no consistent neuropathology across all cases of schizophrenia and preferential areas of dysfunction can be determined. Thus, there seems a collection of subtle neurodevelopmental errors which can lead to various forms of schizophrenia and that at least some types of schizophrenia most probably also involve a neurodegenerative process which could in fact be a consequence of the initial developmental defect.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 22:10:33