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Titolo:
Mental and behavioural outcome of infantile epilepsy treated by vigabatrinin tuberous sclerosis patients
Autore:
Jambaque, I; Chiron, C; Dumas, C; Mumford, J; Dulac, O;
Indirizzi:
Hosp St Vincent de Paul, Dept Pediat Neurol, F-75674 Paris 14, France HospSt Vincent de Paul Paris France 14 Neurol, F-75674 Paris 14, France INSERM, U29, Paris, France INSERM Paris FranceINSERM, U29, Paris, France Univ Paris 05, Paris, France Univ Paris 05 Paris FranceUniv Paris 05, Paris, France Hoechst Marion Roussel, Paris, France Hoechst Marion Roussel Paris France echst Marion Roussel, Paris, France
Titolo Testata:
EPILEPSY RESEARCH
fascicolo: 2-3, volume: 38, anno: 2000,
pagine: 151 - 160
SICI:
0920-1211(200002)38:2-3<151:MABOOI>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHILDREN; SPASMS; CARBAMAZEPINE; MONOTHERAPY; POPULATION; SEIZURES; MEMORY; WEST;
Keywords:
tuberous sclerosis; vigabatrin; infantile spasms; cognitive functions; autism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Chiron, C Hosp St Vincent de Paul, Dept Pediat Neurol, 82 Ave Denfert Rochereau, F-75674 Paris 14, France Hosp St Vincent de Paul 82 Ave Denfert Rochereau Paris France 14
Citazione:
I. Jambaque et al., "Mental and behavioural outcome of infantile epilepsy treated by vigabatrinin tuberous sclerosis patients", EPILEPSY R, 38(2-3), 2000, pp. 151-160

Abstract

Vigabatrin (VGB) has demonstrated high efficacy in infantile spasms (IS) due to tuberous sclerosis. Our first objective was to evaluate the cognitivelong term effect outcome of children whose refractory spasms definitely disappeared when VGB was given as an add on drug. Our second objective was todetermine the response of generalized epilepsy (infantile spasms) comparedto partial epilepsy on cognitive impairment. A non selected series of 13 children underwent psychometric and behavioural evaluation before VGB initiation at a mean of 3 years on VGB treatment. Eight of them could perform detailed neuropsychological tests at follow-up. Seven had infantile spasms (Group I), they all were spasm free before 2 years of age and five remained with rare partial seizures (mean age, 5.5 years). Six others had partial epilepsy without spasms (Group II) and five remained with rare seizures (mean age, 7.5 years). Patients of Group I experienced dramatic changes. Developmental quotient (DQ) significantly rose in six out of seven by ten to more than 45 points (P = 0.03) and autistic behaviour disappeared in five out of the six who presented with. The four tested children had normal verbal levelafter 5 years and could integrate at school but they remained with marked visuospatial disabilities. By contrast, patients of Group II remained with an unchanged DQ of about 60 so that both groups had similar DQ levels on follow-up. The cessation of spasms with VGB is therefore associated with significant improvement of cognition and behaviour in children with tuberous sclerosis. Controlling secondary generalization induced by infantile spasms seems to be a key factor for mental development. (C) 2000 Elsevier Science B. V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 06:51:42