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Titolo:
Interpretation of Wada memory test for lateralization of seizure focus by use of (99m)technetium-HMPAO SPECT
Autore:
Kim, BG; Lee, SK; Kim, JY; Kang, DW; Lee, WO; Song, HC; Lee, DS;
Indirizzi:
Seoul Natl Univ, Coll Med, Dept Neurol, Seoul, South Korea Seoul Natl Univ Seoul South Korea Med, Dept Neurol, Seoul, South Korea Seoul Natl Univ, Coll Med, Dept Nucl Med, Seoul, South Korea Seoul Natl Univ Seoul South Korea ed, Dept Nucl Med, Seoul, South Korea Chonnam Natl Univ, Coll Med, Dept Nucl Med, Kwangju, South Korea Chonnam Natl Univ Kwangju South Korea pt Nucl Med, Kwangju, South Korea
Titolo Testata:
EPILEPSIA
fascicolo: 1, volume: 41, anno: 2000,
pagine: 65 - 70
SICI:
0013-9580(200001)41:1<65:IOWMTF>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRACAROTID AMOBARBITAL PROCEDURE; ANTERIOR TEMPORAL LOBECTOMY; INJECTION; PERFORMANCE; SODIUM; IMPAIRMENT;
Keywords:
intracarotid amobarbital procedure; SPECT; TLE; lateralization; medial temporal region;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Lee, SK Seoul Natl Univ Hosp, Coll Med, Dept Neurol, Chongno Ku, 28 Yunkeun Dong, Seoul 110744, South Korea Seoul Natl Univ Hosp 28 Yunkeun Dong Seoul South Korea 110744 rea
Citazione:
B.G. Kim et al., "Interpretation of Wada memory test for lateralization of seizure focus by use of (99m)technetium-HMPAO SPECT", EPILEPSIA, 41(1), 2000, pp. 65-70

Abstract

Purpose: Although the intracarotid amobarbital procedure (IAP) or Wada test is useful in lateralizing seizure focus in patients with temporal lobe epilepsy (TLE), the results of the LAP memory test are frequently nonlateralizing. An insufficient suppression of the medial temporal region contralateral to the seizure focus may contribute to the failure of lateralization. Wetried to correlate LAP memory results with the functional changes in the contralateral medial temporal region as measured by single photon emission computed tomography (SPECT)during IAP. Methods: We performed a (99m)technetium-(Tc) hexamethylene-propylene-amine-oxime (HMPAO) brain SPECT in 19 medial TLE patients during a contralateralIAP (sodium amobarbital injected contralateral to the seizure focus). Regional cerebral blood flow (rCBF) was measured in the contralateral medial temporal region. The amount of decrease in the rCBF was calculated by subtracting the previous measurement from the one obtained with the interictal SPECT. Results: Ten (53%) patients passed and nine (47%) failed the contralateralIAP. The mean percentage decrease in rCBF was 5.3 +/- 5.3%. There was a significant negative correlation between a decrease in the rCBF and the LAP memory-retention score by Spearman correlation (p = -0.53, p <0.021). Patients with smaller decreases in rCBF (<5%) more frequently passed the contralateral LAP memory test than did those with larger decreases (80 vs. 22%; p <0.023). Conclusions: We suggest that an insufficient suppression of the contralateral medial temporal function is partly responsible for nonlateralizing IAP memory tests. An IAP-SPECT may be useful in interpreting IAP memory tests for the lateralization of seizure focus in TLE patients.

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Documento generato il 11/07/20 alle ore 11:05:54