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Titolo:
Visual electrophysiological effect of a GABA transaminase blocker
Autore:
Harding, GFA; Robertson, KA; Edson, AS; Barnes, P; Wild, J;
Indirizzi:
Aston Univ, Inst Psychol, Clin Neurophysiol Unit, Birmingham B4 7ET, W Midlands, England Aston Univ Birmingham W Midlands England B4 7ET 7ET, W Midlands, England Aston Univ, Vis Sci Res Inst, Birmingham B4 7ET, W Midlands, England AstonUniv Birmingham W Midlands England B4 7ET 7ET, W Midlands, England Hoechst Marion Roussel Ltd, Uxbridge UB9 5HP, Middx, England Hoechst Marion Roussel Ltd Uxbridge Middx England UB9 5HP Middx, England
Titolo Testata:
DOCUMENTA OPHTHALMOLOGICA
fascicolo: 2, volume: 97, anno: 1999,
pagine: 179 - 188
SICI:
0012-4486(1999)97:2<179:VEEOAG>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
VIGABATRIN; EPILEPSY; SYSTEM; RETINA;
Keywords:
electro-oculogram; electroretinogram; vigabatrin; normal subjects; GABA transaminase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Harding, GFA Aston Univ, Inst Psychol, Clin Neurophysiol Unit, Birmingham B4 7ET, W Midlands, England Aston Univ Birmingham W Midlands England B4 7ET nds, England
Citazione:
G.F.A. Harding et al., "Visual electrophysiological effect of a GABA transaminase blocker", DOC OPHTHAL, 97(2), 1999, pp. 179-188

Abstract

Vigabatrin is an antiepileptic drug for the treatment of partial seizures. The anticonvulsant effect is achieved by irreversible inhibition of the enzyme GABA-transaminase which catalyses the inactivation of GABA. Vigabatrinhas been associated with visual field loss and electrophysiological abnormalities. The purpose of the study was to determine any alterations in normal volunteers of the visual field and the visual electrophysiology resultingfrom a short exposure to vigabatrin. A three-way, double-blind study of placebo, carbamazepine and vigabatrin was undertaken at baseline and on days two, four and nine. Seven subjects completed all three cycles and 14 subjects (six females and eight males; mean age 27.3 years SD 6.7) completed at least one cycle. Static threshold automated perimetry comprised Humphrey Visual Field Analyzer Programs 30-2 and 30/60-2. Electro-oculography and electroretinograms were performed with undilated pupils using the Medelec Ganzfeld stimulator GS2000. The visual field was unaffected by placebo, carbamazepine or vigabatrin. The group mean amplitudes and latencies for the scotopic ERG, 30Hz flicker ERG and the oscillatory potentials remained unchanged for any cycle. The group mean photopic ERG b-wave latency increased from baseline (p<0.05); no significant change occurred with carbamazepine or placebo. The group mean Arden Index for vigabatrin decreased from baseline to day9 (p<0.01); no significant differences were present for carbamazepine or placebo. Vigabatrin has a rapid effect on both the photopic ERG and the EGG;however, the changes merely reflect alterations in retinal GABA levels secondary to concomitant blocking of GABA transaminase by existing vigabatrin therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 20:43:39