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Titolo:
Direct influences of pro-inflammatory cytokines (IL-1 beta, TNF-alpha, IL-6) on the proliferation and cell surface antigen expression of cancer cells
Autore:
Kuninaka, S; Yano, T; Yokoyama, H; Fukuyama, Y; Terazaki, Y; Uehara, T; Kanematsu, T; Asoh, H; Ichinose, Y;
Indirizzi:
Kyushu Natl Canc Ctr, Dept Chest Surg, Fukuoka 8111395, Japan Kyushu Natl Canc Ctr Fukuoka Japan 8111395 Surg, Fukuoka 8111395, Japan Kyushu Univ, Dept Surg 2, Fukuoka 812, Japan Kyushu Univ Fukuoka Japan 812 ushu Univ, Dept Surg 2, Fukuoka 812, Japan
Titolo Testata:
CYTOKINE
fascicolo: 1, volume: 12, anno: 2000,
pagine: 8 - 11
SICI:
1043-4666(200001)12:1<8:DIOPC(>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; AUTOCRINE GROWTH-FACTOR; LUNG-CANCER; SIALYL LEWIS(X); CARCINOMA-CELLS; HLA ANTIGENS; IN-VITRO; INTERLEUKIN-6; ADHESION; MELANOMA;
Keywords:
adhesion molecules; human lymphocyte antigen (HLA); metastasis; pro-inflammatory cytokine; proliferation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Ichinose, Y Kyushu Natl Canc Ctr, Dept Chest Surg, Fukuoka 8111395, Japan Kyushu Natl Canc Ctr Fukuoka Japan 8111395 ka 8111395, Japan
Citazione:
S. Kuninaka et al., "Direct influences of pro-inflammatory cytokines (IL-1 beta, TNF-alpha, IL-6) on the proliferation and cell surface antigen expression of cancer cells", CYTOKINE, 12(1), 2000, pp. 8-11

Abstract

Pro-inflammatory cytokines, e.g. interleukin 1 (IL-1), tumour necrosis factor alpha (TNF-alpha), IL-6 produced by surgical intervention or non-specific immunotherapy may directly affect both the growth and the metastasis of tumour cells. It is therefore important to clarify the direct influence of pro-inflammatory cytokines on tumour cells in order to obtain abetter knowledge of anti-tumour therapy. Four human lung cancer cell lines were used. The tumour cells were incubated for 72 h in the presence of various concentrations of IL-1 beta, TNF-alpha, or IL-6 and then the proliferative responsewas assessed by an MTT assay. After 14 days of culture with each pro-inflammatory cytokine, the cell-surface antigen expressions (HLA-class I, HLA-class IT, CEA, sialyl Lewis(x)) were assessed by an immunocytochemical Staining method. Among the various combinations of tumour cells (PC-9, PC-12, QG-56, QG-95) and cytokines (IL-1 beta, TNF-alpha, IL-6), only TNF-alpha significantly exhibited an antiproliferative effect against PC-9 cells. However,various modulations of the cell-surface antigen expression by the cytokines were observed. The HLA-class I antigen expression of PC-9 was augmented by either TNF-alpha or IL-1 beta. Furthermore, IL-1 beta was able to induce CEA in PC-9, QG-56; and QG-95 cells while TNF-a was able to enhance the expression of sialyl Lewisx in QG-95 cells. Although the influence of pro-inflammatory cytokines on the growth of tumour cells was only slight, some modulations of the cell-surface antigen expression were notable. The augmentation of HLA-class I expression can thus improve the immunogenicity of tumour cells while the. induction of CEA or sialyl Lewis(x) may therefore be associated with the promotion of metastasis. (C) 2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/06/20 alle ore 01:51:17