Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Incorporation of the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) into hair of mice
Autore:
Hegstad, S; Ingebrigtsen, K; Reistad, R; Paulsen, JE; Alexander, J;
Indirizzi:
Natl Publ Hlth Inst, Dept Environm Med, N-0403 Oslo, Norway Natl Publ HlthInst Oslo Norway N-0403 Environm Med, N-0403 Oslo, Norway Norwegian Sch Vet Sci, Dept Pharmacol Microbiol & Food Hyg, N-0033 Oslo, Norway Norwegian Sch Vet Sci Oslo Norway N-0033 & Food Hyg, N-0033 Oslo, Norway
Titolo Testata:
BIOMARKERS
fascicolo: 1, volume: 5, anno: 2000,
pagine: 24 - 32
SICI:
1354-750X(200001/02)5:1<24:IOTFM2>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
HETEROCYCLIC AROMATIC-AMINES; HUMAN-URINE; MEAT MEAL; EXPOSURE; ADDUCTS; MEIQX; 2-AMINO-3,8-DIMETHYLIMIDAZO<4,5-F>QUINOXALINE; CARCINOGENS; EXCRETION; OFLOXACIN;
Keywords:
2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP); biomarker; hair; mouse; liquid scintillation counting; autoradiography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Hegstad, S Natl Publ Hlth Inst, Dept Environm Med, POB 4404 Torshov, N-0403 Oslo, Norway Natl Publ Hlth Inst POB 4404 Torshov Oslo Norway N-0403 Norway
Citazione:
S. Hegstad et al., "Incorporation of the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) into hair of mice", BIOMARKERS, 5(1), 2000, pp. 24-32

Abstract

The incorporation of the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) into hair of newborn mice was investigated in order to contribute to the validation of PhIP in hair as a suitable biomarker for human dietary exposure. Black mice (C57BL/6J; 7-9 days old) were given graded doses of [H-3]-PhIP subcutaneously during the start of the hair growth period. The distribution of [H-3]-PhIP and incorporation into hair were investigated by rape-section autoradiography. Almost all the radioactivity in hairrepresented PhIP as shown by high performance liquid chromatography (HPLC)and gas chromatography-mass spectrometry (GC-MS). A dose-response proportionality of incorporation into hair was found when incorporation was determined by liquid scintillation counting. Autoradiography showed that PhIP was rapidly cleared from the skin, but remained for at least 28 days in the part of the hair shafts which was formed during the exposure period. The present results obtained using the mouse as a model, further support the suggestion that PhIP in hair may be a suitable biomarker for human exposure to dietary PhIP.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 19:22:29