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Titolo:
A case of juvenile myelomonocytic leukemia with ocular infiltration
Autore:
Nambu, M; Shimizu, K; Ito, S; Ohta, S;
Indirizzi:
Tenri Hosp, Dept Pediat, Tenri, Nara 6328552, Japan Tenri Hosp Tenri NaraJapan 6328552 pt Pediat, Tenri, Nara 6328552, Japan Tokyo Med & Dent Univ, Dept Pediat, Tokyo, Japan Tokyo Med & Dent Univ Tokyo Japan Dent Univ, Dept Pediat, Tokyo, Japan
Titolo Testata:
ANNALS OF HEMATOLOGY
fascicolo: 12, volume: 78, anno: 1999,
pagine: 568 - 570
SICI:
0939-5555(199912)78:12<568:ACOJML>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC MYELOGENOUS LEUKEMIA;
Keywords:
juvenile myelomonocytic leukemia; ocular infiltration; bone marrow transplantation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Nambu, M Tenri Hosp, Dept Pediat, 200 Mishima Cho, Tenri, Nara 6328552, Japan Tenri Hosp 200 Mishima Cho Tenri Nara Japan 6328552 328552, Japan
Citazione:
M. Nambu et al., "A case of juvenile myelomonocytic leukemia with ocular infiltration", ANN HEMATOL, 78(12), 1999, pp. 568-570

Abstract

We present a case of juvenile myelomonocytic leukemia (JMML) with ocular infiltration. A 1-month-old boy presented with myeloid precursors in peripheral blood and a white blood cell count >10 x 10(9)/l. His peripheral blood monocyte count was >1 x 10(9)/l, bone marrow blasts were <20%, and no Ph chromosome was identified. The boy also presented with hepatosplenomegaly, pallor, fever, and skin rash. We diagnosed this case as JMML, although hemoglobin F was within the normal range and no spontaneous colony growth was observed from peripheral blood mononuclear cells. Neither Epstein-Barr(EB) virus nor cytomegalovirus was detected by PCR in bone marrow aspirate or peripheral blood. The patient had several lesions into which JMML cells might have infiltrated, including skin, liver, spleen, oral cavity, right lung, sigmoid colon, and both eyes. To our knowledge, this is the first reported case of JMML with ocular involvement. Since infiltration of JMML cells into both eyes causes blindness, further consideration of the timing of bone marrow transplantation (BMT) in JMML is necessary.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 00:23:09