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Titolo:
Antagonistic effects of 3 sesquiterpene lactones from Atractylodes macrocephala Koidz on rat uterine contraction in vitro
Autore:
Zhang, YQ; Xu, SB; Lin, YC; Li, Q; Zhang, X; Lai, YR;
Indirizzi:
Zhongshan Univ, Sch Life Sci, Dept Pharm, Lab Pharm & Pharmacol, Guangzhou510275, Peoples R China Zhongshan Univ Guangzhou Peoples R China 510275 u510275, Peoples R China Zhongshan Univ, Dept Appl Chem, Lab Nat Organ Chem, Guangzhou 510275, Peoples R China Zhongshan Univ Guangzhou Peoples R China 510275 510275, Peoples R China Sun Yat Sen Univ Med Sci, Pathol Lab, Guangzhou 510089, Peoples R China Sun Yat Sen Univ Med Sci Guangzhou Peoples R China 510089 eoples R China
Titolo Testata:
ACTA PHARMACOLOGICA SINICA
fascicolo: 1, volume: 21, anno: 2000,
pagine: 91 - 96
SICI:
0253-9756(200001)21:1<91:AEO3SL>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE; UTERUS;
Keywords:
Atractylodes macrocephala; parasympatholytics; uterine contraction; acetylcholine; verapamil; oxytocin; calcium chloride; potassium chloride; diethylstilbestrol;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Xu, SB Zhongshan Univ, Sch Life Sci, Dept Pharm, Lab Pharm & Pharmacol, Guangzhou510275, Peoples R China Zhongshan Univ Guangzhou Peoples R China 510275 , Peoples R China
Citazione:
Y.Q. Zhang et al., "Antagonistic effects of 3 sesquiterpene lactones from Atractylodes macrocephala Koidz on rat uterine contraction in vitro", ACT PHAR SI, 21(1), 2000, pp. 91-96

Abstract

AIM: To study the effects of three sesquiterpene lactones: atractylenolideI (8,9-dehydroasterolide, B), 4, 15-epoxy-8 beta-hydroxyasterolide (C), and atractylenolide III (8 beta-hydroasterolide, D) from Atractylodes macrocephala Koidz, on rat isolated uterus smooth muscle. METHODS: Rat isolated uteri bathed in De Jalon I solution were used; acetylcholine (ACh), CaCl2, and oxytocin (Oxy) were used to evoke the contraction of uterus. RESULTS: B, C, and D 28 or 56 mu mol.L-1 inhibited the spontaneous movement of uterus, reducing their rest force, contractile force, and movement ability. B 28 or56 mu mol.L-1 also slowed down the frequency of uterus spontaneous contraction, but C or D did not. B, C, or D 28 and 56 mu mol.L-1 inhibited the uterine spasm induced by Oxy and ACh. Likewise, Ver 0.28 nmol.L-1, B, C, and D28 or 56 mu mol.L-1 relieved the contraction mediated by CaCl2 in high-KClsolution, but B, C, or D had not marked influence on the maximal response of uterus to CaCl2. CONCLUSION: B, C, and D inhibit the movement of uterus smooth muscle, and the mechanism is related to the inhibition of cholinergic system as well as Ca2+ movement.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/11/20 alle ore 19:50:29