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Titolo:
The state of serotonin protein-transporter in platelets of patients with somatoform disorders
Autore:
Belous, AR; Rammamoorthy, S; Blakely, RD; Factor, MI; Dupin, AM; Katasonov, AB; Lozier, RH; Beniashvili, AG; Morozova, MA; Brusov, OS;
Indirizzi:
Russian Acad Med Sci, Mental Hlth Res Ctr, Dept Endogen Mental Disroders &Affect States, Clin Biochem Lab, Moscow 109801, Russia Russian Acad Med Sci Moscow Russia 109801 hem Lab, Moscow 109801, Russia Vanderbilt Univ, Ctr Med, Ctr Mol Neurosci, Sch Pharmacol, Nashville, TN 37232 USA Vanderbilt Univ Nashville TN USA 37232 Pharmacol, Nashville, TN 37232 USA
Titolo Testata:
ZHURNAL NEVROPATOLOGII I PSIKHIATRII IMENI S S KORSAKOVA
fascicolo: 11, volume: 99, anno: 1999,
pagine: 32 - 35
SICI:
0044-4588(1999)99:11<32:TSOSPI>2.0.ZU;2-R
Fonte:
ISI
Lingua:
RUS
Soggetto:
IMIPRAMINE BINDING-SITES; PLASMA-MEMBRANE VESICLES; HUMAN-BLOOD-PLATELETS; TRITIATED IMIPRAMINE; PARKINSONS-DISEASE; DEPRESSED-PATIENTS; DECREASED UPTAKE; 5-HYDROXYTRYPTAMINE; CLONING; PURIFICATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Belous, AR Russian Acad Med Sci, Mental Hlth Res Ctr, Dept Endogen Mental Disroders &Affect States, Clin Biochem Lab, Moscow 109801, Russia Russian Acad Med Sci Moscow Russia 109801 scow 109801, Russia
Citazione:
A.R. Belous et al., "The state of serotonin protein-transporter in platelets of patients with somatoform disorders", ZH NEVR PS, 99(11), 1999, pp. 32-35

Abstract

The role of serotonin transporter (SERT) protein in the development of somatoform disorders (SD) was investigated. An association study was performedin terms of the evaluation of the level of SERT immunoreactive (IR-SERT) protein using site-specific antibodies directed at SERT C-terminus fragment,poorly conserved among the other cotransporters. The level of the anxious symptomatology was also estimated in the patients with SD. 22 patients, whomet DSM-IV criteria for somatoform disorders, and 32 normals were examined. in platelets from normals, IR-SERT protein migrated as a difuse band between 68 and 105 kDa, and a major sharper band at 43 kDa. Almost complete disappearance of platelet 43 kDa IR-SERT protein band was observed in most of the patients with SD. These findings permitted to suggest a possibility of either biosynthetic or processing abnormality of SERTs in the affected population, that might reflect a dysfunction of serotonin neurotransmission in CNS of the patients with SD.

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Documento generato il 23/01/20 alle ore 18:15:55