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Titolo:
Effects of portal vein clamping time on rat liver microcirculation following extended cold preservation and transplantation
Autore:
Urata, K; Brault, A; Huet, PM;
Indirizzi:
Univ Montreal, Ctr Hosp, Res Ctr, Montreal, PQ H2X 1P1, Canada Univ Montreal Montreal PQ Canada H2X 1P1 tr, Montreal, PQ H2X 1P1, Canada
Titolo Testata:
TRANSPLANT INTERNATIONAL
fascicolo: 6, volume: 12, anno: 1999,
pagine: 408 - 414
SICI:
0934-0874(199911)12:6<408:EOPVCT>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
OF-WISCONSIN SOLUTION; REPERFUSION INJURY; ULTRASTRUCTURAL-CHANGES; ENDOTHELIAL-CELLS; ISCHEMIC STORAGE; EURO-COLLINS; UW-SOLUTION; SURVIVAL; ALLOGRAFTS; MECHANISMS;
Keywords:
liver microcirculation; orthotopic rat liver transplantation; cold preservation; portal vein clamping time;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Huet, PM Univ Montreal, Ctr Hosp, Res Ctr, St Luc Campus,264 E Rene Levesque Blvd, Montreal, PQ H2X 1P1, Canada Univ Montreal St Luc Campus,264 E Rene Levesque Blvd Montreal PQ Canada H2X 1P1
Citazione:
K. Urata et al., "Effects of portal vein clamping time on rat liver microcirculation following extended cold preservation and transplantation", TRANSPLAN I, 12(6), 1999, pp. 408-414

Abstract

Orthotopic rat liver transplantation (ORLT) following extended cold preservation in University of Wisconsin (UW) solution has been shown to induce alterations of the hepatic microcirculation, mainly characterized by areas ofno-reflow The present study was performed to determine whether these alterations were related to the portal vein clamping time (PVCT), shown to be the main determinant of survival after ORLT. The hepatic microcirculation wasevaluated using the multiple-indicator dilution curve (MIDC) technique after ORLT following 24-hour cold ischemia in UW solution. Two groups of rats were studied: one with PVCTs of less than 14 min (survival conditions) and one with PVCTs of more than 18 min (nonsurvival conditions). Four hours after ORLT, only long PVCTs were associated with small, but significant, nonperfused areas, about 10 % of the liver not being perfused by water; however,in both survival and nonsurvival conditions, the sinusoidal sieving function was well-maintained in perfused areas. In addition, liver viability parameters and hepatocyte function were similarly and minimally altered. The hepatic microcirculation is minimally altered 4 h after ORLT following extended cold preservation in UW solution, whatever the survival condition. Although only found after long PVCTs, the low magnitude of areas of no-reflow should not be associated with lethal injury of the transplanted liver, a finding further supporting the concept that survival after ORLT following 24-hour cold preservation in UW solution is mainly influenced by extrahepatic factors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 12:15:41