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Titolo:
Plasma glutamine levels and falciparum malaria
Autore:
Cowan, G; Planche, T; Agbenyega, T; Bedu-Addo, G; Owusu-Ofori, A; Adebe-Appiah, J; Agranoff, D; Woodrow, C; Castell, L; Elford, B; Krishna, S;
Indirizzi:
Univ London St Georges Hosp, Sch Med, Dept Infect Dis, London SW17 0RE, England Univ London St Georges Hosp London England SW17 0RE on SW17 0RE, England John Radcliffe Hosp, Inst Mol Med, Dept Mol Parasitol, Oxford OX3 9DU, England John Radcliffe Hosp Oxford England OX3 9DU itol, Oxford OX3 9DU, England Komfo Anokye Teaching Hosp, Dept Child Hlth, Kumasi, Ghana Komfo Anokye Teaching Hosp Kumasi Ghana Dept Child Hlth, Kumasi, Ghana Univ Oxford, Dept Biochem, Oxford OX1 3QU, England Univ Oxford Oxford England OX1 3QU Dept Biochem, Oxford OX1 3QU, England
Titolo Testata:
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE
fascicolo: 6, volume: 93, anno: 1999,
pagine: 616 - 618
SICI:
0035-9203(199911/12)93:6<616:PGLAFM>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUPPLEMENTATION; METABOLISM; CHILDREN; SYSTEM;
Keywords:
malaria; Plasmodium falciparum; children; glutamine; Ghana;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Krishna, S Univ London St Georges Hosp, Sch Med, Dept Infect Dis, Cranmer Terrace, London SW17 0RE, England Univ London St Georges Hosp Cranmer Terrace London England SW17 0RE
Citazione:
G. Cowan et al., "Plasma glutamine levels and falciparum malaria", T RS TROP M, 93(6), 1999, pp. 616-618

Abstract

Glutamine deficiency is associated with increased rates of sepsis and mortality, which can be prevented by glutamine supplementation. Changes in glutamine concentration were examined in Ghanaian children with acute falciparum malaria and control cases. The mean CSD) plasma glutamine concentration was lower in patients with acute malaria (401 (82) mu mol/L, n = 50) than incontrol patients (623 (67) mu mol/L, n = 7; P < 0 . 001). Plasma glutamineconcentrations all rose in convalescence. The mean (SD) increase in plasmaglutamine was 202 (123) mu mol/L (n = 18; P < 0 . 001) compared with acuteinfection. We conclude that acute falciparum malaria is associated with large decreases in plasma glutamine and these fails may increase susceptibility to sepsis and dyserythropoeisis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 02:41:21