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Titolo:
Hemisynaptic distribution patterns of presenilins and beta-APP isoforms inthe rodent cerebellum and hippocampus
Autore:
Ribaut-Barassin, C; Moussaoui, S; Brugg, B; Haeberle, AM; Huber, G; Imperato, A; Delhaye-Bouchaud, N; Mariani, J; Bailly, YJ;
Indirizzi:
CNRS, UPR 9009, Lab Neurobiol Cellulaire, F-67084 Strasbourg, France CNRSStrasbourg France F-67084 ol Cellulaire, F-67084 Strasbourg, France Rhone Poulenc Rorer, Ctr Rech Vitry Alfortville, Vitry Sur Seine, France Rhone Poulenc Rorer Vitry Sur Seine France lle, Vitry Sur Seine, France Univ Paris 06, Inst Neurosci, Dev Neurobiol Lab, CNRS,UMR 7624, Paris, France Univ Paris 06 Paris France Neurobiol Lab, CNRS,UMR 7624, Paris, France F Hoffmann La Roche & Co Ltd, Div Pharma, Preclin CNS Res, Basel, Switzerland F Hoffmann La Roche & Co Ltd Basel Switzerland Res, Basel, Switzerland
Titolo Testata:
SYNAPSE
fascicolo: 2, volume: 35, anno: 2000,
pagine: 96 - 110
SICI:
0887-4476(200002)35:2<96:HDPOPA>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYLOID PRECURSOR PROTEIN; DISEASE-ASSOCIATED PRESENILIN-1; ALZHEIMERS-DISEASE; MOUSE-BRAIN; RAT-BRAIN; IMMUNOHISTOCHEMICAL ANALYSIS; CORTICAL-NEURONS; EXPRESSION; LOCALIZATION; MICE;
Keywords:
synapse; brain; rodent; immunocytochemistry; electron microscopy; Alzheimer's disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
70
Recensione:
Indirizzi per estratti:
Indirizzo: Bailly, YJ CNRS, UPR 9009, Lab Neurobiol Cellulaire, 5 Rue Blaise Pascal, F-67084 Strasbourg, France CNRS 5 Rue Blaise Pascal Strasbourg France F-67084 urg, France
Citazione:
C. Ribaut-Barassin et al., "Hemisynaptic distribution patterns of presenilins and beta-APP isoforms inthe rodent cerebellum and hippocampus", SYNAPSE, 35(2), 2000, pp. 96-110

Abstract

Healthy brain neurons co-express Alzheimer's disease (AD) related proteinspresenilins (PS) and beta-amyloid precursor protein (beta-APP), Depositionof beta-amyloid and PS in the senile plaques of AD brain and their abilityto interact in vitro suggest that AD pathology could arise from a defect in the physiological interactions between beta-APP and PS within and/or between neurons. The present study compares the immunocytochemical distributionof PS (1 and 2) and beta-APP major isoforms (695 and 751/770) in the synapses of the cerebellum and hippocampus of the adult rat and mouse. In the cerebellar cortex of both species, the four molecules are immunodetected in the presynaptic or the postsynaptic compartments of synapses, suggesting that they are involved in interneuronal relationships. In contrast, PS and beta-APP are postsynaptic in almost all the immunoreactive synapses of the hippocampus. The different distribution patterns of these proteins in cerebellar and hippocampal synapses may reflect specific physiological differences,responsible for differential vulnerability of neurons to AD synaptic pathology. Defective interactions between beta-APP and PS at the synapses could impede the synaptic functions of beta-APP, inducing the selective loss of synapses that accounts for cognitive impairment in AD. (C) 2000 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 07:30:13