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Titolo:
Biology of hepatic stellate cells and their possible relevance in the pathogenesis of portal hypertension in cirrhosis
Autore:
Pinzani, M; Gentilini, P;
Indirizzi:
Univ Florence, Dipartimento Med Interna, I-50134 Florence, Italy Univ Florence Florence Italy I-50134 ed Interna, I-50134 Florence, Italy
Titolo Testata:
SEMINARS IN LIVER DISEASE
fascicolo: 4, volume: 19, anno: 1999,
pagine: 397 - 410
SICI:
0272-8087(1999)19:4<397:BOHSCA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR-BETA; FAT-STORING CELLS; SINUSOIDAL ENDOTHELIAL-CELLS; FIBROTIC HUMAN-LIVER; PERFUSED-RAT-LIVER; COLLAGEN TYPE-I; NITRIC-OXIDE; GENE-EXPRESSION; ITO CELLS; EXTRACELLULAR-MATRIX;
Keywords:
hepatic stellate cell; liver fibrosis; portal hypertension; endothelin-1; nitric oxide;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
113
Recensione:
Indirizzi per estratti:
Indirizzo: Pinzani, M Univ Florence, Dipartimento Med Interna, Viale GB Morgagni 85, I-50134 Florence, Italy Univ Florence Viale GB Morgagni 85 Florence Italy I-50134 taly
Citazione:
M. Pinzani e P. Gentilini, "Biology of hepatic stellate cells and their possible relevance in the pathogenesis of portal hypertension in cirrhosis", SEM LIV DIS, 19(4), 1999, pp. 397-410

Abstract

In the past 10 years we have witnessed an exponential increase in the knowledge on the development and progression of liver fibrosis. At present, liver fibrogenesis is referred to as a dynamic process involving complex cellular and molecular mechanisms, resulting from the chronic activation of the tissue repair mechanisms that follows reiterated liver tissue injury. The identification and characterization of the cell types and of the different mediators involved in this process has allowed a "revisitation" of several issues related to liver cirrhosis and its immediate consequences. Among these, evaluation of the relationships occurring between fibrogenesis and portal hypertension, cholestasis, and the development of hepatocellular carcinoma represent some of the hottest areas of research in the field of hepatology. Our aim is to establish a link between the available knowledge on the biology of hepatic stellate cells and their possible implication in the genesis and progression of portal hypertension.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 09:40:56