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Titolo:
Expression of tPA, LH receptor and inhibin alpha, beta(A) subunits during follicular atresia in rats
Autore:
Yan, JL; Feng, Q; Liu, HZ; Fu, GQ; Liu, YX;
Indirizzi:
Chinese Acad Sci, State Key Lab Reprod Biol, Inst Zool, Beijing 100080, Peoples R China Chinese Acad Sci Beijing Peoples R China 100080 100080, Peoples R China
Titolo Testata:
SCIENCE IN CHINA SERIES C-LIFE SCIENCES
fascicolo: 6, volume: 42, anno: 1999,
pagine: 583 - 590
SICI:
1006-9305(199912)42:6<583:EOTLRA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMINOGEN-ACTIVATOR ACTIVITY; GRANULOSA-CELL APOPTOSIS; CUMULUS-OOCYTE COMPLEXES; ESTROGENS;
Keywords:
atresia; LH receptor; inhibin subunit; tissue plasminogen activator; in situ hybridization; immunohistochemistry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Liu, YX Chinese Acad Sci, State Key Lab Reprod Biol, Inst Zool, Beijing 100080, Peoples R China Chinese Acad Sci Beijing Peoples R China 100080 Peoples R China
Citazione:
J.L. Yan et al., "Expression of tPA, LH receptor and inhibin alpha, beta(A) subunits during follicular atresia in rats", SCI CHINA C, 42(6), 1999, pp. 583-590

Abstract

By using DNA 3'-end labeling, immunocytochemistry and mRNA in situ hybridization detection techniques, the expression of inhibin subunits and LH receptor in the granulosa cells and tissue-type plasminogen activator (tPA) in the oocytes has been studied in relation to follicular development and atresia. The results demonstrated that: (i) tPA activity in the oocytes of normal developing follicles is undetectable, and increases significantly in thefollicle undergoing atresia; (ii) the production of inhibin subunits in granulosa cells is negatively correlated with the expression of oocyte tPA activity, indicating that they may be an important regulator of oocyte tPA production and follicular development; (iii) in atretic follicles, granulosa cells do not express LH receptor and inhibin subunits. It is therefore suggested that tPA may play a role in oocyte self-destruction and clearance in some of atretic follicles, and inhibin of granulosa-origin might be an inhibitory factor for the translation of tPA in the oocyte.

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Documento generato il 14/07/20 alle ore 02:43:26