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Titolo:
Malignant mesothelioma: clinical and therapeutic study
Autore:
Boutin, C; Monnet, I; Ruffie, P; Astoul, P;
Indirizzi:
Hop Concept, Serv Pneumol, F-13385 Marseille 5, France Hop Concept Marseille France 5 Serv Pneumol, F-13385 Marseille 5, France
Titolo Testata:
REVUE DES MALADIES RESPIRATOIRES
fascicolo: 6BIS, volume: 16, anno: 1999,
pagine: 1317 - 1326
SICI:
0761-8425(199912)16:6BIS<1317:MMCATS>2.0.ZU;2-W
Fonte:
ISI
Lingua:
FRE
Soggetto:
LEUKEMIA GROUP-B; PHASE-II TRIAL; PLEURAL MESOTHELIOMA; PROGNOSTIC FACTORS; CELL-LINES; MULTIMODALITY THERAPY; ASBESTOS EXPOSURE; INTERFERON-GAMMA; MITOMYCIN-C; DIFFUSE;
Keywords:
mesothelioma; screening; thoracoscopy; treatment;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Boutin, C Hop Concept, Serv Pneumol, 147 Blvd Baille, F-13385 Marseille 5,France Hop Concept 147 Blvd Baille Marseille France 5 seille 5, France
Citazione:
C. Boutin et al., "Malignant mesothelioma: clinical and therapeutic study", REV MAL RES, 16(6BIS), 1999, pp. 1317-1326

Abstract

Like lung cancer, mesothelioma is difficult to diagnose early. Nevertheless disease stage is the determinant factor for outcome of treatment. Effective diagnostic examinations must be undertaken promptly. Thoracoscopy is oneof the best diagnostic procedures provided that it is skillfully performedto prevent complications such as development of subcutaneous nodules alongthe pathway of the trocar. Several arguments have been proposed against routine screening including low incidence of the disease, poor sensitivity and specificity of screening techniques, and lack of effective therapy documented by phase III study. However there are a number of arguments in favor of screening. The highrisk population is well defined. Although no control study is currently available, promising new results have been observed in limited forms, i.e., 62 % response rate at stage IA with 39 % survival at 5 years in patients presenting epithelial forms without lymph node involvementtreated by pleuro-pneumonectomy, chemotherapy, and radiotherapy. Screeningis necessary to recruit more early-stage patients for further clinical trials to improve therapeutic techniques. Poor outcome of treatment could be due It, delayed diagnosis. Early diagnosis is also needed to allow compensation of occupational disease to begin while the patient is still alive.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:35:58