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Titolo:
Breathing pattern in patients with Parkinson's disease
Autore:
Vercueil, L; Linard, JP; Wuyam, B; Pollak, P; Benchetrit, G;
Indirizzi:
Fac Med Grenoble, F-38700 La Tronche, France Fac Med Grenoble La TroncheFrance F-38700 e, F-38700 La Tronche, France CHU, INSERM U318, Neurol Clin, F-38700 La Tronche, France CHU La TroncheFrance F-38700 8, Neurol Clin, F-38700 La Tronche, France
Titolo Testata:
RESPIRATION PHYSIOLOGY
fascicolo: 2-3, volume: 118, anno: 1999,
pagine: 163 - 172
SICI:
0034-5687(199912)118:2-3<163:BPIPWP>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
PULMONARY-FUNCTION; DYSFUNCTION; MUSCLES;
Keywords:
disease, Parkinson; mammals, humans. pattern of breathing; Parkinson's disease; pharmacological agents, levodopa;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Benchetrit, G Fac Med Grenoble, F-38700 La Tronche, France Fac Med Grenoble La Tronche France F-38700 Tronche, France
Citazione:
L. Vercueil et al., "Breathing pattern in patients with Parkinson's disease", RESP PHYSL, 118(2-3), 1999, pp. 163-172

Abstract

The improvement in motor performance resulting from levodopa administration in patients with Parkinson's disease (PD) provides the opportunity to investigate ventilatory changes brought about by the disease. The aim of this study has been to investigate these changes in order to specify the mechanisms of the impairment in breathing in PD. Breathing patterns at rest were investigated in 11 patients with idiopathic PD both before (OFF) and after (ON) administration of levodopa at a dose improving their motor performance by at least 30%. Airflow (Fleisch head mounted on a mask), rib cage and abdomen movements (inductance plethysmography) were recorded in the OFF condition 1 h after subjects woke up. Subjects then received levodopa and a new set of recordings was obtained 1 h later, in the ON condition. Breath-by-breath processing of recordings was carried out and tidal volume (VT), inspiratory (TI) and expiratory (TE) durations were measured. The main finding wasa lengthening of TI resulting in a decrease in ventilation and in VT/TI. and an increase ill TI/TTOT in the ON compared to the OFF. condition. In theON condition abnormal rib cage-abdomen plots patterns were found in four out of six subjects. A hypothesis on the effect of PD on breathing is proposed on grounds of normal diaphragmatic activity but impaired activity of theother respiratory muscles and more specifically the intercostal muscles. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 17:49:16