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Titolo:
Broadsheet number 52: Molecular genetics of colorectal cancer
Autore:
Jass, JR;
Indirizzi:
Univ Queensland, Sch Med, Dept Pathol, Herston, Qld 4006, Australia Univ Queensland Herston Qld Australia 4006 , Herston, Qld 4006, Australia
Titolo Testata:
PATHOLOGY
fascicolo: 4, volume: 31, anno: 1999,
pagine: 354 - 364
SICI:
0031-3025(199911)31:4<354:BN5MGO>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONPOLYPOSIS COLON-CANCER; DNA-REPLICATION ERRORS; II RECEPTOR GENE; MICROSATELLITE MUTATOR PHENOTYPE; SOMATIC FRAMESHIFT MUTATIONS; RILEY-RUVALCABA-SYNDROME; MISMATCH REPAIR; STAGE-II; JUVENILE POLYPOSIS; GENOMIC INSTABILITY;
Keywords:
colorectal cancer; molecular mechanisms; morphogenesis; classification; diagnosis;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
131
Recensione:
Indirizzi per estratti:
Indirizzo: Jass, JR Univ Queensland, Sch Med, Dept Pathol, Herston, Qld 4006, Australia Univ Queensland Herston Qld Australia 4006 , Qld 4006, Australia
Citazione:
J.R. Jass, "Broadsheet number 52: Molecular genetics of colorectal cancer", PATHOLOGY, 31(4), 1999, pp. 354-364

Abstract

The molecular genetics of colorectal cancer is presented in an order that ascends from the basic to the applied: molecular mechanisms, morphogenesis,classification and diagnosis. Major consideration is given to the nature of genetic instability and the role of this mechanism in driving neoplastic progression. It is shown how the fundamental principle of genetic instability cuts across applied research, tissue diagnosis and clinical management with respect to both sporadic and inherited forms of colorectal cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 07:28:00