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Titolo:
DIASTEREOSELECTIVE SYNTHESIS OF 2'-DEOXY AND 2'-O-METHYL DINUCLEOSIDE(3',5')-METHYLPHOSPHONATES VIA ALKOXYMAGNESIUM CHLORIDE-MEDIATED NUCLEOSIDE COUPLING
Autore:
DAILY WJ; SCHWARTZ DA; RILEY TA; ARNOLD LJ; MARVIN WB; SCURRIA MA; HOPKINS SA; ATKINS MB; GARCIA CD; PIRRUNG MC;
Indirizzi:
JBL SCI INC,277 GRANADA DR SAN LUIS OBISPO CA 93401 GENTA INC SAN DIEGO CA 92121 DUKE UNIV,DEPT CHEM DURHAM NC 27708
Titolo Testata:
Nucleosides & nucleotides
fascicolo: 4, volume: 16, anno: 1997,
pagine: 417 - 432
SICI:
0732-8311(1997)16:4<417:DSO2A2>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
STEREOSPECIFIC SYNTHESIS; GENE-EXPRESSION; METHYLPHOSPHONATES; METHANEPHOSPHONATES); OLIGONUCLEOTIDES; CONFIGURATION; INHIBITORS; ACID;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
W.J. Daily et al., "DIASTEREOSELECTIVE SYNTHESIS OF 2'-DEOXY AND 2'-O-METHYL DINUCLEOSIDE(3',5')-METHYLPHOSPHONATES VIA ALKOXYMAGNESIUM CHLORIDE-MEDIATED NUCLEOSIDE COUPLING", Nucleosides & nucleotides, 16(4), 1997, pp. 417-432

Abstract

A diastereoselective dinucleoside methylphosphonate synthetic method that features coupling of diastereomerically pure 1,1,1,3,3,3-hexafluoro-2-propyl nucleoside-3'-O-methylphosphonate monomers with 3'-O-protected nucleoside monomers mediated by alkoxymagnesium chloride reagentsis described. This synthetic method was found to be diastereospecificin the synthesis of selected 2'-deoxy dinucleoside methyphosphonates and diastereoselective in the synthesis of all sixteen 2'-O-methyl dinucleoside methylphosphonates.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 21:54:43