Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Respiratory health surveillance in a toluene di-isocyanate production unit, 1967-97: clinical observations and lung function analyses
Autore:
Ott, MG; Klees, JE; Poche, SL;
Indirizzi:
BASF Corp, Corp Med Dept, Mt Olive, NJ 07828 USA BASF Corp Mt Olive NJ USA 07828 rp, Corp Med Dept, Mt Olive, NJ 07828 USA BASF Corp, Geismar Med Dept, Geismar, LA USA BASF Corp Geismar LA USABASF Corp, Geismar Med Dept, Geismar, LA USA
Titolo Testata:
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
fascicolo: 1, volume: 57, anno: 2000,
pagine: 43 - 52
SICI:
1351-0711(200001)57:1<43:RHSIAT>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
OCCUPATIONAL ASTHMA; BRONCHIAL RESPONSIVENESS; DIISOCYANATE; EXPOSURE; WORKERS; ADULTS; SYSTEM; PLANT;
Keywords:
toluene di-isocyanate; lung function decrement; occupational asthma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Ott, MG BASF Corp, Corp Med Dept, Mt Olive, NJ 07828 USA BASF Corp Mt Olive NJ USA 07828 Med Dept, Mt Olive, NJ 07828 USA
Citazione:
M.G. Ott et al., "Respiratory health surveillance in a toluene di-isocyanate production unit, 1967-97: clinical observations and lung function analyses", OCC ENVIR M, 57(1), 2000, pp. 43-52

Abstract

Objectives-To characterise irritant and allergic airway responses and assess changes in forced vital capacity (FVC) and forced expiratory volume in 1second (FEV,) relative to exposure di-isocyanate (TDI). Methods-Employees (n=313) ever assigned to a TDI production unit for greater than or equal to 3 months (1967-92) were identified from personnel records along with 158 frequency matched referents without known exposure to TDI. Reports made during visits to the occupational clinic of incidents related to exposure to TDI and annual periodic examination results (questionnaire, physical findings, and spirometry) were abstracted and assessed relative to industrial hygiene estimates of exposure to TDI. Results-Mean 8 hour time weighted average estimates of TDI concentrations ranged from 9.9 ppb in jobs with potentially high exposure during the earlyyears of plant operations to 0.5 ppb in jobs with potentially low exposurein more recent years. The corresponding rates of visits to the clinic due to incidents of exposure to TDI (including both irritant and allergic airway responses) declined from 20.5 to 1.0 visits per 100 years of employment at the unit. The annual incidence of asthma induced by TDI declined from 1.8% before 1980 to 0.7% afterwards. Neither cross sectional nor longitudinal analyses of FVC and FEV, showed significant dose-response findings relativeto exposure to TDI across the total exposed population. Among cases of occupational asthma there was an apparent initial decline in FEV, within 2 years of first reporting symptoms, but not an accelerated rate of decline in follow up tests from 4-30 years after induction of asthma. Conclusions-Occurrences of both asthma induced by TDI and irritant airway responses due to exposure to TDI were found in this cohort, but there was no relation between cumulative exposure to TDI and irreversible airflow obstruction as assessed by spirometry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/02/20 alle ore 20:52:35