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Titolo:
A pyrene seco-pseudonucleoside in constructing interaction-sensitive fluorescent DNA probes
Autore:
Korshun, VA; Balakin, KV; Proskurina, TS; Mikhalev, II; Malakhov, AD; Berlin, YA;
Indirizzi:
Russian Acad Sci, Shemyakin Ovchinnikov Inst Bioorgan Chem, Moscow 117871,Russia Russian Acad Sci Moscow Russia 117871 ioorgan Chem, Moscow 117871,Russia
Titolo Testata:
NUCLEOSIDES & NUCLEOTIDES
fascicolo: 11-12, volume: 18, anno: 1999,
pagine: 2661 - 2676
SICI:
0732-8311(1999)18:11-12<2661:APSICI>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEIC-ACID HYBRIDIZATION; RESONANCE ENERGY-TRANSFER; EXCIMER FLUORESCENCE; LABELED OLIGONUCLEOTIDES; RESIDUES; BINDING; OLIGODEOXYNUCLEOTIDES; SPECTROSCOPY; NUCLEOSIDE; SUBSTRATE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Berlin, YA Russian Acad Sci, Shemyakin Ovchinnikov Inst Bioorgan Chem, Ul Miklukho Maklaya 16-10,GSP-7, Moscow 117871, Russia Russian Acad Sci Ul Miklukho Maklaya 16-10,GSP-7 Moscow Russia 117871
Citazione:
V.A. Korshun et al., "A pyrene seco-pseudonucleoside in constructing interaction-sensitive fluorescent DNA probes", NUCLEOS NUC, 18(11-12), 1999, pp. 2661-2676

Abstract

Based on 4-(1-pyrenyl)-1,3-butanediol, a pyrene seco-pseudonucleoside, we prepared a nonnucleotide phosphoramidite reagent and a pyrene-modified LCAA-CPG-support and employed them in solid-phase synthesis of pyrene-labeled oligonucleotides with varying numbers and positions of the pseudonucleoside residues. Changes in the fluorescence intensity and the spectral curve shape upon hybridization were observed that depended on the position(s) of the modified unit(s) in the probe.

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Documento generato il 19/09/20 alle ore 07:49:16