Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
GLUCAGON-LIKE PEPTIDE-1 7-36-AMIDE AND PEPTIDE YY HAVE ADDITIVE INHIBITORY EFFECT ON GASTRIC-ACID SECRETION IN MAN
Autore:
WETTERGREN A; MAINA P; BOESBY S; HOLST JJ;
Indirizzi:
UNIV COPENHAGEN,PANUM INST,DEPT MED PHYSIOL,BLEGDAMSVEJ 3 DK-2200 COPENHAGEN N DENMARK UNIV COPENHAGEN,PANUM INST,DEPT MED PHYSIOL DK-2200 COPENHAGEN N DENMARK GLOSTRUP CTY HOSP,DEPT GASTROINTESTINAL SURG D COPENHAGEN DENMARK
Titolo Testata:
Scandinavian journal of gastroenterology
fascicolo: 6, volume: 32, anno: 1997,
pagine: 552 - 555
SICI:
0036-5521(1997)32:6<552:GP7APY>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
PANCREATIC FUNCTIONS; ENDOCRINE-CELLS; HUMANS; GUT; RELEASE; GLP-1; PYY; IMMUNOREACTIVITY; NEUROTENSIN; GLICENTIN;
Keywords:
ENTEROGASTRONE; GASTRIC ACID; PENTAGASTRIN; PEPTIDE YY; PROGLUCAGON;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
A. Wettergren et al., "GLUCAGON-LIKE PEPTIDE-1 7-36-AMIDE AND PEPTIDE YY HAVE ADDITIVE INHIBITORY EFFECT ON GASTRIC-ACID SECRETION IN MAN", Scandinavian journal of gastroenterology, 32(6), 1997, pp. 552-555

Abstract

Background: Glucagon-like peptide-1 7-36 amide (GLP-1) and peptide YY(PYY) are colocalized in the L-cell of the ileal mucosa, and both peptides may function as enterogastrone hormones. However, it is not known whether they interact with regard to the effect on acid secretion. Methods: The effect of intravenous infusion of GLP-1 and PYY, either alone or in combination, on pentagastrin-induced acid secretion in eighthealthy volunteers was examined. The peptides were infused at two different rates: 0.25 pmol/kg/min (low rate) and 0.5 pmol/kg/min (high rate). Results: Given alone, GLP-1 and PYY inhibited acid secretion by 26 +/- 5% and 18 +/- 5% (low rate) and 45 +/- 8% and 38 +/- 7% (high rate), respectively. Combined infusion resulted in an inhibition of 32 +/- 5% (low rate) and 62 +/- 7% (high rate). Both infusion rates resulted in GLP-1 and PYY plasma concentrations below or similar to postprandial levels. Conclusion: The present study suggests that the interaction between GLP-1 and PYY in man is of the additive type. The results indicate that GLP-1 and PYY have an important role in the physiologic control of gastric acid secretion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:34:26