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Titolo:
In vitro proton and phosphorus NMR spectroscopic analysis of murine (C57Bl/6J) brain development
Autore:
Yao, FS; Caserta, MT; Wyrwicz, AM;
Indirizzi:
Northwestern Univ, Sch Med, Dept Psychiat & Behav Sci, Chicago, IL 60611 USA Northwestern Univ Chicago IL USA 60611 & Behav Sci, Chicago, IL 60611 USA Northwestern Univ, Sch Med, Ctr MR Res, ENH Res Inst,Dept Anesthesiol, Chicago, IL 60611 USA Northwestern Univ Chicago IL USA 60611 Anesthesiol, Chicago, IL 60611 USA Northwestern Univ, Dept Neurobiol & Physiol, Evanston, IL 60201 USA Northwestern Univ Evanston IL USA 60201 & Physiol, Evanston, IL 60201 USA
Titolo Testata:
NMR IN BIOMEDICINE
fascicolo: 7, volume: 12, anno: 1999,
pagine: 463 - 470
SICI:
0952-3480(199911)12:7<463:IVPAPN>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; DEVELOPING RAT-BRAIN; METABOTROPIC GLUTAMATE RECEPTORS; POSTNATAL-DEVELOPMENT; CEREBRAL-CORTEX; ENDOGENOUS GLUTAMATE; N-ACETYLASPARTATE; TAURINE CONTENT; BINDING-SITES; P-31 NMR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Yao, FS Ctr MR Res, 1033 Univ Pl,Suite 150, Evanston, IL 60201 USA Ctr MR Res 1033 Univ Pl,Suite 150 Evanston IL USA 60201 60201 USA
Citazione:
F.S. Yao et al., "In vitro proton and phosphorus NMR spectroscopic analysis of murine (C57Bl/6J) brain development", NMR BIOMED, 12(7), 1999, pp. 463-470

Abstract

We report for the first time in vitro proton and phosphorus NMR spectroscopic analyses of murine brain development from fetal to adult stages. Chloroform-methanol extracts from C57B16/J mouse brain, at ages ranging from 15 days in utero (F15) to adult, permitted the simultaneous investigation of both cytosolic and membrane phospholipid compartments. The protein content ofmurine brain was determined and used for quantitation of individual metabolite levels. Proton NMR spectroscopy revealed that NAA, considered a neuronal marker, is undetectable at F15. Glutamate, GABA and creatine, however, are present at this time. All four compounds reach maximum levels at 21 dayspostnatal (P21). Choline and alanine levels are at their peak in fetal brain and progressively fall as the brain develops. Phosphorus NMR spectroscopy shows that phosphatidylcholine, phosphatidylinositol, sphingomyelin, and phosphatidylserine increase steadily from F15 to P21. Copyright (C) 1999 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 12:16:49