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Titolo:
Continuous saturation EPI with diffusion weighting at 3.0 T
Autore:
Francis, ST; Gowland, PA; Bowtell, RW;
Indirizzi:
Univ Nottingham, Magnet Resonance Ctr, Sch Phys & Astron, Nottingham NG7 2RD, England Univ Nottingham Nottingham England NG7 2RD , Nottingham NG7 2RD, England
Titolo Testata:
NMR IN BIOMEDICINE
fascicolo: 7, volume: 12, anno: 1999,
pagine: 440 - 450
SICI:
0952-3480(199911)12:7<440:CSEWDW>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; RECOVERY FAIR TECHNIQUE; ARTERIAL WATER; PERFUSION; BRAIN; INVERSION; MAGNETIZATION; VALUES; FMRI;
Keywords:
perfusion; spin labelling; EPI; high field; continuous saturation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Bowtell, RW Univ Nottingham, Magnet Resonance Ctr, Sch Phys & Astron, Nottingham NG7 2RD, England Univ Nottingham Nottingham England NG7 2RD NG7 2RD, England
Citazione:
S.T. Francis et al., "Continuous saturation EPI with diffusion weighting at 3.0 T", NMR BIOMED, 12(7), 1999, pp. 440-450

Abstract

This paper presents a steady-state method of arterial spin labelling usingcontinuous saturation in conjunction with echo-planar imaging (EPI), whichhas been implemented at 3 T, The continuous saturation technique has the advantage of having high sensitivity compared to transient labelling techniques. when long repetition times are used. It is also easy to implement and requires minimal data to be acquired for quantitation. Like other arterial spin labelling techniques, continuous saturation is potentially prone to overestimation of perfusion rates due to the effect of tagged blood in vessels within the image slice. Using a simple model of the vasculature, the degree of diffusion weighting required to suppress the arterial signal has beendetermined, with the results indicating that a value of 2 s/mm(2) is adequate. Histogram analysis of the experimental data has been used to evaluate the effect of diffusion weighting. Using a b-value of 2 s/mm(2), the mean perfusion-related signal change in grey matter on continuous saturation was found to be 1.5 +/- 0.2%, yielding a mean perfusion rate of 87 +/- 9 ml/100g/min. Brain activation studies using the diffusion weighted continuous saturation technique gave a mean increase in perfusion of 36 +/- 12% in activated motor cortex. Copyright (C) 1999 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 07:59:00