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Titolo:
Role of supraspinal tachykinins for volume- and L-dopa-induced bladder activity in normal conscious rats
Autore:
Ishizuka, O; Igawa, Y; Nishizawa, O; Andersson, KE;
Indirizzi:
Shinshu Univ, Sch Med, Dept Urol, Matsumoto, Nagano 3908621, Japan ShinshuUniv Matsumoto Nagano Japan 3908621 sumoto, Nagano 3908621, Japan Univ Lund Hosp, Dept Clin Pharmacol, S-22185 Lund, Sweden Univ Lund Hosp Lund Sweden S-22185 Clin Pharmacol, S-22185 Lund, Sweden
Titolo Testata:
NEUROUROLOGY AND URODYNAMICS
fascicolo: 1, volume: 19, anno: 2000,
pagine: 101 - 109
SICI:
0733-2467(2000)19:1<101:ROSTFV>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
MICTURITION REFLEX; URINARY-BLADDER; SUBSTANCE-P; SPINAL-CORD; OUTLET OBSTRUCTION; LOCUS COERULEUS; NK2 RECEPTOR; CAPSAICIN; ANTAGONIST; HYPERACTIVITY;
Keywords:
neurokinins; NK-receptor antagonists; cystometry; intracerebroventricular administration;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Ishizuka, O Shinshu Univ, Sch Med, Dept Urol, Asahi 3-1-1, Matsumoto, Nagano 3908621, Japan Shinshu Univ Asahi 3-1-1 Matsumoto Nagano Japan 3908621 Japan
Citazione:
O. Ishizuka et al., "Role of supraspinal tachykinins for volume- and L-dopa-induced bladder activity in normal conscious rats", NEUROUROL U, 19(1), 2000, pp. 101-109

Abstract

To clarify the rules of tachykinins in volume-induced micturition and in bladder hyperactivity, presumed to originate from supraspinal structures, normal, female Sprague-Dawley rats were investigated cystometrically before and after intracerebroventricular (i.c.v) administration of RP 67,580, a selective antagonist of NK-1 receptors, and/or SR 48,968, a selective antagonist of NK-2 receptors. The effects of RP 67,580 and SR 48,968 on intraperitoneal (i.p. ) L-dopa-induced bladder hyperactivity were also investigated. I.c.v. administration of RP 67,580 (20 nmol) SR 48,968 (20 nmol) suppressed micturition. Combination of i.c.v. RP 67,580(2 nmol) and SR 48,968 (2 nmol) significantly decreased micturition pressure (18%), and increased bladder capacity (26%), micturition volume (18%), and residual volume (223%). In rats pretreated with i.p. carbidopa 50 mg/kg, i.p. L-dopa 50 mg/kg caused bladder hyperactivity that was attenuated by the combination of i.c.v. RP 67,580 (2 nmol) and SR 48,968 (2 nmol). The results suggest that tachykinins, via stimulation of NK receptors in supraspinal structures, are involved in both volume and L-dopa-induced stimulation of bladder activity. This may imply that tachykinins can influence both the supraspinal and spinal control ofthe urinary bladder. it also implies that supraspinal NK receptors are a possible target for drugs aimed fur elimination of bladder hyperactivity mediated via these pathways. (C) 2000 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 03:33:41