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Titolo:
Effects of pudendal nerve injury in the female rat
Autore:
Kerns, JM; Damaser, MS; Kane, JM; Sakamoto, K; Benson, JT; Shott, S; Brubaker, L;
Indirizzi:
Rush Presbyterian St Lukes Med Ctr, Dept Anat, Chicago, IL 60612 USA Rush Presbyterian St Lukes Med Ctr Chicago IL USA 60612 ago, IL 60612 USA Rush Presbyterian St Lukes Med Ctr, Dept Obstet & Gynecol, Chicago, IL 60612 USA Rush Presbyterian St Lukes Med Ctr Chicago IL USA 60612 ago, IL 60612 USA Loyola Univ, Med Ctr, Dept Urol, Maywood, IL 60153 USA Loyola Univ Maywood IL USA 60153 ed Ctr, Dept Urol, Maywood, IL 60153 USA Edward Hines Vet Adm Hosp, Hines, IL 60141 USA Edward Hines Vet Adm Hosp Hines IL USA 60141 dm Hosp, Hines, IL 60141 USA Indiana Univ, Dept Obstet & Gynecol, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 ynecol, Indianapolis, IN 46202 USA Rush Presbyterian St Lukes Med Ctr, Dept Neurosurg, Chicago, IL 60612 USA Rush Presbyterian St Lukes Med Ctr Chicago IL USA 60612 ago, IL 60612 USA
Titolo Testata:
NEUROUROLOGY AND URODYNAMICS
fascicolo: 1, volume: 19, anno: 2000,
pagine: 53 - 69
SICI:
0733-2467(2000)19:1<53:EOPNII>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
PELVIC-FLOOR; URINARY-INCONTINENCE; BIRTH; CONTINENCE; LESIONS; DAMAGE; REGENERATION; ORGANIZATION; PARTURITION; COMPONENTS;
Keywords:
pudendal nerve crush; micturition; voiding; electromyogram, external urethral sphincter;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Kerns, JM Rush Presbyterian St Lukes Med Ctr, Dept Anat, 1653 W Congress Pkwy, Chicago, IL 60612 USA Rush Presbyterian St Lukes Med Ctr 1653 W Congress Pkwy Chicago IL USA 60612
Citazione:
J.M. Kerns et al., "Effects of pudendal nerve injury in the female rat", NEUROUROL U, 19(1), 2000, pp. 53-69

Abstract

To test a neurogenic hypothesis for external urethral sphincter (EUS) dysfunction associated with urinary incontinence, the proximal pudendal nerve was crushed in anesthetized retired breeder female rats (n = 5) and comparedwith a sham lesion group (n = 4). Outcome measures included concentric needle electromyograms (EMGs) from the target EUS, voiding patterns during a 2-hour dark period, and micturition data over a 24-hour period. Fast Blue (FB) was introduced to the crush site at the time of injury and Diamidino Yellow (DY) to the EUS at the time the rats were killed (3 months post-operative), when histological analysis of the nerve and urethra was also performed. EMG records indicated the EUS motor units undergo typical denervation changes followed by regeneration and recovery. Voiding patterns from the crushgroup show a significant increase of small urine marks in the front third of the cage. At 1-2 weeks post-op, the frequency of voids was significantlyincreased in the crush group compared to pre-op and late post-op time periods. The mean volume voided in the light phase at the early post-op time was significantly increased in the sham group. Light and electron microscopicpatterns seen in nerve and muscle suggest the regenerating motor units maintain a structural integrity. Motoneurons in the lower lumbar cord were labeled with either DY (14.5 +/- 6.8), FB (31.7 +/- 23.7), or both (35.0 +/- 17.5) tracers, indicating similar to 54% of che crushed pudendal neurons regenerated to the EUS. In conclusion, several measures suggest this reversible crush lesion induces mild urinary incontinence. This animal model is promising for further development of hypotheses regarding neural injury, the pathogenesis of incontinence, and strategies aimed at prevention and treatment. (C) 2000 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 13:19:57