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Titolo:
The dopamine d2 receptor gene is a susceptibility locus for Parkinson's disease
Autore:
Oliveri, RL; Annesi, G; Zappia, M; Civitelli, D; De Marco, EV; Pasqua, AA; Annesi, F; Spadafora, P; Gambardella, A; Nicoletti, G; Branca, D; Caracciolo, M; Aguglia, U; Quattrone, A;
Indirizzi:
Univ Catanzaro, Inst Neurol, Dept Med Sci, Catanzaro, Italy Univ Catanzaro Catanzaro Italy t Neurol, Dept Med Sci, Catanzaro, Italy Natl Res Council, Inst Expt Med & Biotechnol, Mangone, CS, Italy Natl Res Council Mangone CS Italy t Med & Biotechnol, Mangone, CS, Italy
Titolo Testata:
MOVEMENT DISORDERS
fascicolo: 1, volume: 15, anno: 2000,
pagine: 127 - 131
SICI:
0885-3185(200001)15:1<127:TDDRGI>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONOAMINE-OXIDASE; DRD2 LOCUS; POLYMORPHISM; ASSOCIATION; SCHIZOPHRENIA; BINDING; ALLELE; RFLP;
Keywords:
Parkinson's disease; dopamine D2 receptor; polymorphism association; genetics;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Quattrone, A Policlin Univ Materdomini, Neurol Clin, Via T Campanella, I-88100 Catanzaro, Italy Policlin Univ Materdomini Via T Campanella CatanzaroItaly I-88100
Citazione:
R.L. Oliveri et al., "The dopamine d2 receptor gene is a susceptibility locus for Parkinson's disease", MOVEMENT D, 15(1), 2000, pp. 127-131

Abstract

The dopamine D2 receptor (DRD2) gene has been proposed as a candidate geneunderlying several psychiatric and neurologic disorders. The aim of the present study was to examine if selected polymorphisms in the DRD2 gene are associated with Parkinson's disease (PD). We determined the allelic frequencies for four polymorphisms located in the DRD2 gene in a sample of 135 patients with PD and 202 normal control subjects. No significant difference wasobserved in the allelic frequencies between patients with PD and control subjects with regard to the -141C Ins/Del and the Ser(311)/Cys(311) variants. On the contrary, the Al allele of the TaqIA polymorphism and the B1 allele of the TaqIB polymorphism were more frequent in patients with PD than in control subjects (control subjects: TaqIA A1 = 14.6%, TaqIB B1 = 10.6% patients with PD: TaqIA Al = 20.7%, TaqIB B1 = 17.4%): Patients carrying the Alallele or the B1 allele had an increased risk of developing PD (TaqIA, odds ratio: 1.71, 95% confidence intervals: 1.08-2.73; TaqIB, odds ratio: 1.83, 95% confidence intervals: 1.12-3.02). The TaqIA and TaqIB polymorphisms were in strong linkage disequilibrium, suggesting that these two polymorphisms convey the same information about the risk of presenting with PD. Genetic variation in the DRD2 gene may influence the risk of developing PD, thus confirming that the DRD2 gene is a susceptibility locus for PD.

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Documento generato il 25/02/20 alle ore 08:06:56