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Titolo:
Atypical antipsychotics in persons with developmental disabilities
Autore:
Aman, MG; Madrid, A;
Indirizzi:
Ohio State Univ, Nisonger Ctr, Columbus, OH 43210 USA Ohio State Univ Columbus OH USA 43210 isonger Ctr, Columbus, OH 43210 USA Pfizer Inc, New York, NY USA Pfizer Inc New York NY USAPfizer Inc, New York, NY USA
Titolo Testata:
MENTAL RETARDATION AND DEVELOPMENTAL DISABILITIES RESEARCH REVIEWS
fascicolo: 4, volume: 5, anno: 1999,
pagine: 253 - 263
SICI:
1080-4013(1999)5:4<253:AAIPWD>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
D2-DOPAMINE RECEPTOR OCCUPANCY; SELF-INJURIOUS-BEHAVIOR; MENTAL-RETARDATION; DOPAMINE-RECEPTOR; AUTISTIC DISORDER; DOUBLE-BLIND; NEW-GENERATION; RISPERIDONE; CLOZAPINE; ADULTS;
Keywords:
atypical antipsychotics; classic antipsychotics; mental retardation; autistic disorder; pervasive developmental disorder-NOS; dopamine; serotonin; neurochemistry;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Aman, MG Ohio State Univ, Nisonger Ctr, 1581 Dodd Dr, Columbus, OH 43210 USA Ohio State Univ 1581 Dodd Dr Columbus OH USA 43210 , OH 43210 USA
Citazione:
M.G. Aman e A. Madrid, "Atypical antipsychotics in persons with developmental disabilities", MENT RET D, 5(4), 1999, pp. 253-263

Abstract

The introduction of clozapine spawned the development of several novel antipsychotic agents during the last decade. Compared to traditional agents, these "atypical antipsychotics" demonstrate more favorable characteristics in terms of efficacy and medication-associated abnormal involuntary movements. Several underlying neurochemical mechanisms have been posited for the differences noted between traditional and atypical antipsychotic drugs. Most theories have been based on the observation that atypical agents have higher affinities and greater selectivity for different dopamine receptor subtypes and for serotonin receptors. In addition, there is speculation about theinvolvement of other types of neurotransmitters (e.g., gamma-aminobutyric acid, N-methyl-D-aspartate) in the actions of these drugs. A review of the current literature on the developmental disabilities indicated that the study populations can be divided into three general categories: (a) individuals with mental retardation and a psychiatric syndrome; (b) individuals with mental retardation and behavioral problems; and (c) individuals with autismand other pervasive developmental disorders. The atypical antipsychotics most consistently appeared to reduce symptoms of self-injury, aggression, agitation, and repetitive behaviors. It is not yet clear whether they enhanceprosocial behavior, although findings of some reports suggested this. A clear limitation of the available evidence is that few studies are methodologically sound. Suggestions for further research are offered. (C) 1999 Wiley-Liss, Inc.

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Documento generato il 29/01/20 alle ore 19:15:52