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Titolo:
Cocaine administration decreases functional connectivity in human primary visual and motor cortex as detected by functional MRI
Autore:
Li, SJ; Biswal, B; Li, Z; Risinger, R; Rainey, C; Cho, JK; Salmeron, BJ; Stein, EA;
Indirizzi:
Med Coll Wisconsin, Biophys Res Inst, Milwaukee, WI 53226 USA Med Coll Wisconsin Milwaukee WI USA 53226 s Inst, Milwaukee, WI 53226 USA Med Coll Wisconsin, Dept Psychiat, Milwaukee, WI 53226 USA Med Coll Wisconsin Milwaukee WI USA 53226 ychiat, Milwaukee, WI 53226 USA Med Coll Wisconsin, Dept Pharmacol, Milwaukee, WI 53226 USA Med Coll Wisconsin Milwaukee WI USA 53226 rmacol, Milwaukee, WI 53226 USA
Titolo Testata:
MAGNETIC RESONANCE IN MEDICINE
fascicolo: 1, volume: 43, anno: 2000,
pagine: 45 - 51
SICI:
0740-3194(200001)43:1<45:CADFCI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
ECHO-PLANAR MRI; HUMAN BRAIN; ACTIVATION; FLUCTUATIONS; REGISTRATION; FMRI; FLOW;
Keywords:
fMRI; cocaine addiction; functional connectivity; human brain; physiological fluctuations;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Li, SJ Med Coll Wisconsin, Biophys Res Inst, 8701 Watertown Plank Rd, Milwaukee, WI 53226 USA Med Coll Wisconsin 8701 Watertown Plank Rd Milwaukee WIUSA 53226 A
Citazione:
S.J. Li et al., "Cocaine administration decreases functional connectivity in human primary visual and motor cortex as detected by functional MRI", MAGN RES M, 43(1), 2000, pp. 45-51

Abstract

Functional magnetic resonance imaging (fMRI) was conducted to observe the effects of cocaine administration on the physiological fluctuations of fMRIsignal in two brain regions. Seven long-term cocaine users with an averageage of 32 years and 8 years of cocaine use history were recruited for the study. A T-2*-weighted fast echo-planar imaging (EPI) pulse sequence was employed at 1.5 T to acquire three sets of brain images for each subject under three conditions (at rest, after saline injection, and after cocaine injection [0.57 mg/kg]), Cross-correlation maps were constructed using the synchronous, low frequency signal from voxel time courses after filtering respiratory, cardiac, and other physiological noise. A quantitative evaluation of the changes in functional connectivity was made using spatial correlationcoefficient (SCC) analysis. A marked 50% reduction in SCC values in the region of primary visual cortex and 43% reduction in SCC values in the regionof primary motor cortex were observed after cocaine administration. This significant reduction in SCC values in these cortical regions is a reflection of changes in neuronal activity. It is suggested that the observed changes in low frequency components after acute cocaine administration during a resting, no-task situation may be used as a baseline reference source when assessing the effects of cocaine on task-driven activation or on mesolimbic dopamine pathways. Magn Reson Med 43:45-51, 2000. (C) 2000 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 02:58:56