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Titolo:
Quantitative perfusion imaging in carotid artery stenosis using dynamic susceptibility contrast-enhanced magnetic resonance imaging
Autore:
Lythgoe, DJ; Ostergaard, L; Williams, SCR; Cluckie, A; Buxton-Thomas, M; Simmons, A; Markus, HS;
Indirizzi:
Inst Psychiat, Neuroimaging Res Grp, London SE5 8AF, England Inst Psychiat London England SE5 8AF ng Res Grp, London SE5 8AF, England
Titolo Testata:
MAGNETIC RESONANCE IMAGING
fascicolo: 1, volume: 18, anno: 2000,
pagine: 1 - 11
SICI:
0730-725X(200001)18:1<1:QPIICA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; CEREBROVASCULAR RESERVE CAPACITY; POSITRON-EMISSION-TOMOGRAPHY; COMPUTED-TOMOGRAPHY; BOLUS TRACKING; OCCLUSION; DISEASE; VOLUME; REACTIVITY; CURVES;
Keywords:
dynamic contrast-enhanced magnetic resonance imaging; cerebral blood flow; cerebral blood volume; mean transit time; carotid artery stenosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Williams, SCR Inst Psychiat, Neuroimaging Res Grp, De Crespigny Pk,DenmarkHill, London SE5 8AF, England Inst Psychiat De Crespigny Pk,Denmark Hill London England SE5 8AF
Citazione:
D.J. Lythgoe et al., "Quantitative perfusion imaging in carotid artery stenosis using dynamic susceptibility contrast-enhanced magnetic resonance imaging", MAGN RES IM, 18(1), 2000, pp. 1-11

Abstract

Quantitative, multislice dynamic susceptibility contrast-enhanced MRI perfusion measurements were used to determine the patterns of cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT), and normalized first moment of the tissue Delta R-2-time curve (N) in 11 subjects withcarotid artery occlusion or stenosis. MTT correlated with degree of carotid stenosis, whereas a range of alterations in CBF and CBV were found presumably reflecting variables degrees of collateral flow. There was no significant correlation between MRI and SPET flow perfusion measurements, with increasing disparity between the two techniques at higher inter-hemispheric flow ratios. The effect of obtaining the arterial input function (AIF) from the middle cerebral artery (MCA) ipsilateral or contralateral to the stenosiswas determined. Despite the use of an AIF from the MCA, which is distal tothe circle of Willis, and hence the major sources of collateral supply, there was still some extra dispersion of the contrast agent bolus due to differences in arrival time. (C) 2000 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 15:05:16