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Titolo:
Cholesterol reduction improves myocardial perfusion abnormalities in patients with coronary artery disease and average cholesterol levels
Autore:
Mostaza, JM; Gomez, MV; Gallardo, F; Salazar, ML; Martin-Jadraque, R; Plaza-Celemin, L; Gonzalez-Maqueda, I; Martin-Jadraque, L;
Indirizzi:
Inst Salud Carlos III, Unidad Arteriosclerosis, Ctr Invest Clin, Atherosclerosis Unit, Madrid 28029, Spain Inst Salud Carlos III Madrid Spain 28029rosis Unit, Madrid 28029, Spain Inst Salud Carlos III, Unidad Arteriosclerosis, Nucl Med Sect, Madrid 28029, Spain Inst Salud Carlos III Madrid Spain 28029 l Med Sect, Madrid 28029, Spain Inst Salud Carlos III, Unidad Arteriosclerosis, Serv Cardiol, Madrid 28029, Spain Inst Salud Carlos III Madrid Spain 28029 rv Cardiol, Madrid 28029, Spain Hosp La Paz, Coronary Unit, Madrid, Spain Hosp La Paz Madrid SpainHosp La Paz, Coronary Unit, Madrid, Spain
Titolo Testata:
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
fascicolo: 1, volume: 35, anno: 2000,
pagine: 76 - 82
SICI:
0735-1097(200001)35:1<76:CRIMPA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; FOREARM RESISTANCE VESSELS; ENDOTHELIAL DYSFUNCTION; HYPERCHOLESTEROLEMIC HUMANS; SERUM-CHOLESTEROL; TL-201 TOMOGRAPHY; LOWERING THERAPY; ANGINA-PECTORIS; RISK-FACTORS; ATHEROSCLEROSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Mostaza, JM Inst Salud Carlos III, Unidad Arteriosclerosis, Ctr Invest Clin, Atherosclerosis Unit, Sinesio Delgado 10, Madrid 28029, Spain Inst SaludCarlos III Sinesio Delgado 10 Madrid Spain 28029 n
Citazione:
J.M. Mostaza et al., "Cholesterol reduction improves myocardial perfusion abnormalities in patients with coronary artery disease and average cholesterol levels", J AM COL C, 35(1), 2000, pp. 76-82

Abstract

OBJECTIVES We sought to evaluate whether pravastatin treatment increases myocardial perfusion, as assessed by thallium-201 single-photon emission computed tomographic (SPECT) dipyrid-amole testing, in patients with coronary artery disease (CAD) and average cholesterol levels. BACKGROUND Previous studies in hypercholesterolemic patients hale demonstrated that cholesterol reduction restores peripheral and coronary endothelium-dependent vasodilation and increases myocardial perfusion. METHODS This was a randomized, placebo-controlled study with a cross-over design. Twenty patients with CAD were randomly assigned to receive 20 mg ofpravastatin or placebo for 16 weeks and then were crossed over to the opposite medication for a further 16 weeks. Lipid and lipoprotein analysis and dipyridamole thallium-201 SPECT were performed at the end of each period. The SPECT images were visually analyzed in eight myocardial segments using a4-point scoring system by two independent observers. A summed stress scoreand a summed rest score were obtained for each patient. Quantitative evaluation was performed by the Cedars-Sinai method. The magnitude of the defectwas expressed as a percentage of global myocardial perfusion. RESULTS Total and low density lipoprotein cholesterol levels during placebo were 214 +/- 29 mg/dl and 148 +/- 25 mg/dl, respectively. These levels with pravastatin were 170 +/- 23 mg/dl and 103 +/- 23 mg/dl, respectively. The summed stress score and summed rest score were lower with pravastatin than with placebo (7.2 +/- 2.3 vs. 5.9 +/- 2.3, p = 0.012 and 3.2 +/- 1.6 vs. 2.4 +/- 2.2, p = 0.043, respectively). Quantitative analysis showed a smaller perfusion defect with pravastatin (29.2%) as compared with placebo (33.8%) (p = 0.021) during dipyridamole stress. No differences were found at rest. CONCLUSIONS Reducing cholesterol levels with pravastatin in patients with CAD improves myocardial perfusion during dipyridamole stress thallium-201 SPECT. (C) 1999 by the American College of Cardiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 08:18:28