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Titolo:
Measurement of local DNA reorganization on the picosecond and nanosecond time scales
Autore:
Brauns, EB; Madaras, ML; Coleman, RS; Murphy, CJ; Berg, MA;
Indirizzi:
Univ S Carolina, Dept Chem & Biochem, Columbia, SC 29208 USA Univ S Carolina Columbia SC USA 29208 m & Biochem, Columbia, SC 29208 USA Ohio State Univ, Dept Chem, Columbus, OH 43210 USA Ohio State Univ Columbus OH USA 43210 , Dept Chem, Columbus, OH 43210 USA
Titolo Testata:
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
fascicolo: 50, volume: 121, anno: 1999,
pagine: 11644 - 11649
SICI:
0002-7863(199912)121:50<11644:MOLDRO>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
SITE-SPECIFIC DYNAMICS; SOLVATION DYNAMICS; MOLECULAR-DYNAMICS; NUCLEIC-ACIDS; B-DNA; MAGNETIC-RESONANCE; RAMAN-SPECTROSCOPY; ELECTRON-TRANSFER; ANISOTROPY DECAY; COUMARIN-153;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
67
Recensione:
Indirizzi per estratti:
Indirizzo: Coleman, RS Univ S Carolina, Dept Chem & Biochem, Columbia, SC 29208 USA Univ S Carolina Columbia SC USA 29208 Columbia, SC 29208 USA
Citazione:
E.B. Brauns et al., "Measurement of local DNA reorganization on the picosecond and nanosecond time scales", J AM CHEM S, 121(50), 1999, pp. 11644-11649

Abstract

Picosecond and nanosecond dynamics in the interior of DNA are observed forthe first time as a dynamic Stokes shift in the fluorescence of a specially designed base-pair analogue. A recently synthesized coumarin C-riboside has been incorporated into an oligonucleotide in place of a normal purine pyrimidine base pair. The dynamic Stokes shift of this probe occurs with components near 300 ps and 13 ns. These times are too long for solvent relaxation or simple vibrational motion of the DNA framework. They imply that the interior of DNA is a unique dynamic environment unlike either a fluid or a molecular crystal.

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Documento generato il 28/11/20 alle ore 04:18:27